Dennis Eickelbeck
Ruhr University Bochum
8 Papers
15 Citations
Dennis Eickelbeck is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: G protein-coupled receptor & Opsin. The author has an hindex of 5, co-authored 7 publications.
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Papers
Lamprey Parapinopsin (“UVLamP”): a Bistable UV-Sensitive Optogenetic Switch for Ultrafast Control of GPCR Pathways
Dennis Eickelbeck,Till Rudack,Stefan Alexander Tennigkeit,Tatjana Surdin,Raziye Karapinar,Jan‐Claudius Schwitalla,Brix Mücher,Maiia Shulman,Marvin Scherlo,Philipp Althoff,Melanie D. Mark,Klaus Gerwert,Stefan Herlitze +12 more
TL;DR: UVLamP is a bistable UV‐sensitive opsin that allows for precise and sustained optogenetic control of G protein‐coupled receptor (GPCR) pathways and can be switched on, but more importantly also off within milliseconds via lowintensity short light pulses, minimizing phototoxicity.
37
Visual tuning in the flashlight fish Anomalops katoptron to detect blue, bioluminescent light.
Melanie D. Mark,Marcel Donner,Dennis Eickelbeck,Jennifer Stepien,Minou Nowrousian,Ulrich Kück,Frank Paris,Jens Hellinger,Stefan Herlitze +8 more
TL;DR: The results suggest that the A. katoptron visual system is optimized to detect blue light in the frequency range of its own bioluminescence and residual starlight and the spectral peak of in vivo electroretinogram (ERG) measurements.
Design of an Ultrafast G Protein Switch Based on a Mouse Melanopsin Variant.
Stefan Alexander Tennigkeit,Raziye Karapinar,Till Rudack,Max-Aylmer Dreier,Philipp Althoff,Dennis Eickelbeck,Tatjana Surdin,Michelle Grömmke,Melanie D. Mark,Katharina Spoida,Mathias Lübben,Udo Höweler,Stefan Herlitze,Klaus Gerwert +13 more
TL;DR: A hybrid strategy for targeted protein engineering combining computational techniques with electrophysiological and UV/visible spectroscopic experiments is presented and the concept for channelrhodopsin‐2 is validated and applied to modify the less‐well‐studied vertebrate opsin melanopsin.
9
Optogenetic Approaches for Controlling Neuronal Activity and Plasticity
Dennis Eickelbeck,Raziye Karapinar,Stefan Herlitze,Katharina Spoida +3 more
- 01 Jan 2018
TL;DR: This chapter provides an overview of the latest molecular and engineering approaches to create a variety of optogenetic tools, which render neurons responsive to light, by introducing different types of microbial and vertebrate light-activated proteins, their general properties, and applications.
8
Understanding melanopsin using bayesian generative models − an Introduction
TL;DR: This application of modeling melanopsin dynamics demonstrates several benefits of Bayesian methods, which directly model uncertainty of parameters, are flexible in the distributions and relations of parameters in the modeling, and allow including prior knowledge, for example parameter values based on biochemical data.