Denise Galatis
University of Melbourne
21 Papers
697 Citations
Denise Galatis is an academic researcher from University of Melbourne. The author has contributed to research in topics: Amyloid precursor protein & P3 peptide. The author has an hindex of 16, co-authored 21 publications. Previous affiliations of Denise Galatis include Mental Health Research Institute.
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Papers
Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
James A. Duce,Andrew Tsatsanis,Michael A. Cater,Simon James,Elysia Robb,Krutika Wikhe,Su Ling Leong,Keyla Perez,Timothy Johanssen,Mark Greenough,Hyun-Hee Cho,Denise Galatis,Robert D. Moir,Colin L. Masters,Catriona McLean,Rudolph E. Tanzi,Roberto Cappai,Kevin J. Barnham,Giuseppe D. Ciccotosto,Jack T. Rogers,Jack T. Rogers,Ashley I. Bush +21 more
TL;DR: This article found that the AD β-amyloid protein precursor possesses ferroxidase activity mediated by a conserved H-ferritin-like active site, which is inhibited specifically by endogenous Zn(2+)-laden amyloid aggregates and correlates with Aβ burden.
631
Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain A REGULATOR OF NEURONAL COPPER HOMEOSTASIS
Kevin J. Barnham,William J. McKinstry,Gerd Multhaup,Denise Galatis,Craig J. Morton,Cyril C. Curtain,Cyril C. Curtain,Nicholas A. Williamson,Anthony R. White,Mark G. Hinds,Raymond S. Norton,Konrad Beyreuther,Colin L. Masters,Michael W. Parker,Roberto Cappai +14 more
TL;DR: The structure of the APP copper binding domain (CuBD) is solved and it is found that it contains a novel copper binding site that favors Cu(I) coordination, consistent with the CuBD acting as a neuronal metallotransporter.
285
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
Jamie Rossjohn,Roberto Cappai,Roberto Cappai,Susanne C. Feil,Anna Henry,Anna Henry,William J. McKinstry,Denise Galatis,Denise Galatis,Lars Hesse,Gerd Multhaup,Konrad Beyreuther,Colin L. Masters,Colin L. Masters,Michael W. Parker +14 more
TL;DR: Structural similarities with cysteine-rich growth factors, taken together with its known growth-promoting properties, suggests the APP N-terminal domain could function as a growth factor in vivo.
257
Interaction of the Molecular Chaperone αB-Crystallin with α-Synuclein: Effects on Amyloid Fibril Formation and Chaperone Activity
Agata Rekas,Christopher G. Adda,J. Andrew Aquilina,J. Andrew Aquilina,Kevin J. Barnham,Margaret Sunde,Denise Galatis,Nicholas A. Williamson,Colin L. Masters,Robin F. Anders,Carol V. Robinson,Roberto Cappai,John A. Carver +12 more
TL;DR: It is reported that αB-crystallin, a molecular chaperone found in Lewy bodies that are characteristic of Parkinson's disease (PD), is a potent in vitro inhibitor of α-synuclein fibrillization, both of wild-type and the two mutant forms that cause familial, early onset PD.
226
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
Olav M. Andersen,Vanessa Schmidt,Robert Spoelgen,Jørgen Gliemann,Joachim Behlke,Denise Galatis,William J. McKinstry,Michael W. Parker,Colin L. Masters,Bradley T Hyman,Roberto Cappai,Thomas E. Willnow +11 more
TL;DR: The respective protein interacting domains are dissected to shed new light on the molecular determinants of neuronal APP trafficking and processing and on possible targets for intervention with senile plaque formation in patients with AD.
172