Denali Boon
Johns Hopkins University
21 Papers
44 Citations
Denali Boon is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Medicine & Virus. The author has an hindex of 11, co-authored 17 publications. Previous affiliations of Denali Boon include National Institutes of Health.
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Papers
Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure.
TL;DR: Care must be taken in interpreting RT-PCR tests for SARS-CoV-2 infection—particularly early in the course of infection—when using these results as a basis for removing precautions intended to prevent onward transmission.
Chimpanzees as an animal model for human norovirus infection and vaccine development
Karin Bok,Gabriel I. Parra,Tanaji Mitra,Eugenio J. Abente,Charlene K. Shaver,Denali Boon,Ronald E. Engle,Claro Yu,Albert Z. Kapikian,Stanislav V. Sosnovtsev,Robert H. Purcell,Kim Y. Green +11 more
TL;DR: The chimpanzee is established as a viable animal model for the study of norovirus replication and immunity, and it is shown that NV VLP vaccines could induce protective homologous immunity even after extended periods of time.
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Comparative Evolution of GII.3 and GII.4 Norovirus over a 31-Year Period
Denali Boon,Jackie E. Mahar,Jackie E. Mahar,Eugenio J. Abente,Carl D. Kirkwood,Robert H. Purcell,Albert Z. Kapikian,Kim Y. Green,Karin Bok +8 more
TL;DR: This study suggests that G.II.3 noroviruses caused disease as early as 1975 and that they evolve via a specific pattern, responding to selective pressures induced by the host rather than presenting a nucleotide evolution rate lower than that of GII.4 norovirus, as previously proposed.
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Prevalence of Hepatitis B and Hepatitis D Virus Infections in the United States, 2011-2016.
TL;DR: In the U.S. household population aged 18 years (2011-2016), prevalence of hepatitis B surface antigen was 0.36% overall, and was highest in non-Hispanic Asians (3.4%), and among adult HBsAg-carriers, 42% had antibodies to hepatitis D virus (anti-HDV).
B cell gene signature with massive intrahepatic production of antibodies to hepatitis B core antigen in hepatitis B virus–associated acute liver failure
Patrizia Farci,Giacomo Diaz,Zhaochun Chen,Sugantha Govindarajan,Ashley Tice,Liane Agulto,Stefania Pittaluga,Denali Boon,Claro Yu,Ronald E. Engle,Mark Haas,Richard Simon,Robert H. Purcell,Fausto Zamboni +13 more
TL;DR: It is shown that liver tissue collected at the time of liver transplantation in two patients with HBV-associated ALF is characterized by an overwhelming B cell response apparently centered in the liver with massive accumulation of plasma cells secreting IgG and IgM, accompanied by complement deposition, suggesting that humoral immunity may exert a primary role in the pathogenesis ofHBV- associated ALF.
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