Dejiang Tan
Istituto Superiore di Sanità
9 Papers
5 Citations
Dejiang Tan is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 5, co-authored 6 publications.
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Papers
The Extra Cytoplasmic Function Sigma Factor σE Is Essential for Mycobacterium tuberculosis Virulence in Mice
Riccardo Manganelli,Lanfranco Fattorini,Dejiang Tan,Elisabetta Iona,Graziella Orefici,Giuseppe Altavilla,Paola Cusatelli,Issar Smith +7 more
TL;DR: The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice and induced formation of granulomas with different characteristics than those induced by the wild-type strain.
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mRNA cancer vaccines: Advances, trends and challenges
TL;DR: In 2019, the U.S. Food and Drug Administration (FDA) approved the first mRNA-based coronavirus disease 2019 (COVID-19) vaccine produced by Pfizer and BioNTech, which generated enthusiasm for mRNA vaccine research and development as discussed by the authors .
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The Mycobacterium tuberculosis Sigma Factor σB Is Required for Full Response to Cell Envelope Stress and Hypoxia In Vitro, but It Is Dispensable for In Vivo Growth
P. A. Fontán,Martin I. Voskuil,Martin I. Voskuil,Manuel Gómez,Dejiang Tan,Manuela Pardini,Riccardo Manganelli,Lanfranco Fattorini,Gary K. Schoolnik,Issar Smith +9 more
TL;DR: The M. tuberculosis sigB mutant strain exposed to cell envelope stress, oxidative stress, and hypoxia was especially defective in survival under hypoxic conditions in vitro, but it was not attenuated for growth in THP-1 cells or during mouse and guinea pig infection.
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Activities of Moxifloxacin Alone and in Combination with Other Antimicrobial Agents against Multidrug-Resistant Mycobacterium tuberculosis Infection in BALB/c Mice
Lanfranco Fattorini,Dejiang Tan,Elisabetta Iona,Maurizio Mattei,Federico Giannoni,Lara Brunori,Simona Recchia,Graziella Orefici +7 more
TL;DR: The activity of moxifloxacin was enhanced by the addition of ethionamide but not by that of cycloserine, thiacetazone, capreomycin, para-aminosalicylic acid, or linezolid in BALB/c mice infected with a strain of Mycobacterium tuberculosis resistant to isoniazid, rifampin, and six other drugs.
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Involvement of the fadD33 gene in the growth of Mycobacterium tuberculosis in the liver of BALB/c mice.
Laura Rindi,Lanfranco Fattorini,Daniela Bonanni,Elisabetta Iona,Giulia Freer,Dejiang Tan,Gianni Dehò,Graziella Orefici,Carlo Garzelli +8 more
TL;DR: Findings suggest that fadD33 plays a role in M. tuberculosis virulence by supporting bacterial growth in the liver, but did not affect replication in the lungs and spleen.