Deepak Kaushal
Texas Biomedical Research Institute
170 Papers
704 Citations
Deepak Kaushal is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Biology & Tuberculosis. The author has an hindex of 43, co-authored 122 publications. Previous affiliations of Deepak Kaushal include Johns Hopkins University & St. Jude Children's Research Hospital.
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Papers
BNT162b vaccines protect rhesus macaques from SARS-CoV-2.
Annette B. Vogel,Isis Kanevsky,Ye Che,Kena A. Swanson,Alexander Muik,Mathias Vormehr,Lena M. Kranz,Kerstin C. Walzer,Stephanie Hein,Alptekin Güler,Jakob Loschko,Mohan S. Maddur,Ayuko Ota-Setlik,Tompkins Kristin Rachael,Journey Cole,Bonny Gaby Lui,Thomas Ziegenhals,Arianne Plaschke,David Eisel,Sarah C. Dany,Stephanie Fesser,Stephanie Erbar,Ferdia Bates,Diana Schneider,Bernadette Jesionek,Bianca Sänger,Ann Kathrin Wallisch,Yvonne Feuchter,Hanna Junginger,Stefanie A. Krumm,Andre P. Heinen,Petra Adams-Quack,Julia Schlereth,Stefan Schille,Christoph Kröner,Ramón de la Caridad Güimil Garcia,Thomas Hiller,Leyla Fischer,Rani S. Sellers,Shambhunath Choudhary,Olga Gonzalez,Fulvia Vascotto,Matthew R. Gutman,Jane Fontenot,Shannan Hall-Ursone,Kathleen M. Brasky,Matthew C. Griffor,Seungil Han,Andreas A.H. Su,Joshua A. Lees,Nicole L. Nedoma,Ellene H. Mashalidis,Parag Sahasrabudhe,Charles Tan,Danka Pavliakova,Guy Singh,Camila R. Fontes-Garfias,Michael W. Pride,Ingrid L. Scully,Tara Ciolino,Jennifer Obregon,Michal Gazi,Ricardo Carrion,Kendra J. Alfson,Warren Kalina,Deepak Kaushal,Pei Yong Shi,Thorsten Klamp,Corinna Rosenbaum,Andreas Kuhn,Özlem Türeci,Philip R. Dormitzer,Kathrin U. Jansen,Ugur Sahin +73 more
TL;DR: In this article, the authors report the preclinical development of two vaccine candidates (BNT162b1 and BNT 162b2) that contain nucleoside-modified messenger RNA that encodes immunogens derived from the spike glycoprotein (S) of SARS-CoV-2, formulated in lipid nanoparticles.
Long-term in vitro expansion alters the biology of adult mesenchymal stem cells.
Reza Izadpanah,Deepak Kaushal,Christopher Kriedt,Fern Tsien,Bindiya Patel,Jason Dufour,Bruce A. Bunnell +6 more
TL;DR: Functional analysis of genes that were differentially expressed in rASCs and hBMSCs revealed that pathways involved in cell cycle, cell cycle checkpoints, protein-ubiquitination, and apoptosis were altered.
361
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Fatai S. Oladunni,Jun-Gyu Park,Paula A. Pino,Olga Gonzalez,Anwari Akhter,Anna Allué-Guardia,Angélica Olmo-Fontánez,Angélica Olmo-Fontánez,Shalini Gautam,Andreu Garcia-Vilanova,Chengjin Ye,Kevin Chiem,Kevin Chiem,Colwyn A. Headley,Varun Dwivedi,Laura M. Parodi,Kendra J. Alfson,Hilary M. Staples,Alyssa Schami,Alyssa Schami,Juan Ignacio García,Alison Whigham,Roy N. Platt,Michal Gazi,Jesse Martinez,Colin Chuba,Stephanie Earley,Oscar H. Rodriguez,Stephanie Davis Mdaki,Katrina N. Kavelish,Renee Escalona,Cory R. A. Hallam,Corbett Christie,Jean L. Patterson,Tim J. Anderson,Ricardo Carrion,Edward J. Dick,Shannan Hall-Ursone,Larry S. Schlesinger,Xavier Alvarez,Deepak Kaushal,Luis D. Giavedoni,Joanne Turner,Luis Martinez-Sobrido,Jordi B. Torrelles +44 more
TL;DR: Transgenic mice expressing human angiotensin-converting enzyme 2 by the human cytokeratin 18 promoter represent a susceptible rodent model and represent a suitable animal model for the study of viral pathogenesis and for identification and characterization of vaccines and antivirals for SARS-CoV-2 infection and associated severe COVID-19 disease.
Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298.
TL;DR: Results suggest that miR-298 directly modulates P-gp expression and is associated with the chemoresistant mechanisms of metastatic human breast cancer, which has diagnostic and therapeutic potential for predicting doxorubicin chemoresistance in human breast cancers.
280
Unexpected Role for IL-17 in Protective Immunity against Hypervirulent Mycobacterium tuberculosis HN878 Infection
Radha Gopal,Leticia Monin,Samantha Slight,Uzodinma Uche,Emmeline Blanchard,Beth A. Fallert Junecko,Rosalío Ramos-Payán,Rosalío Ramos-Payán,Christina L. Stallings,Todd A. Reinhart,Jay K. Kolls,Deepak Kaushal,Uma M. Nagarajan,Javier Rangel-Moreno,Shabaana A. Khader,Shabaana A. Khader +15 more
TL;DR: It is reported here that lab adapted Mtb strains, such as H37Rv, or less virulent Mtb clinical isolates, do not require IL-17 for protective immunity against infection while infection with Mtb HN878 requires IL- 17 for early protective immunity.