Deena R. Altman
Icahn School of Medicine at Mount Sinai
41 Papers
103 Citations
Deena R. Altman is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Methicillin-resistant Staphylococcus aureus. The author has an hindex of 16, co-authored 30 publications. Previous affiliations of Deena R. Altman include Washington University in St. Louis.
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Papers
Genomic confirmation of vancomycin-resistant Enterococcus transmission from deceased donor to liver transplant recipient.
Ali Bashir,Oliver Attie,Mitchell J. Sullivan,Robert Sebra,Kavindra V. Singh,Deena R. Altman,Theodore R. Pak,Jayeeta Dutta,Kieran I. Chacko,Elizabeth Webster,Martha J. Lewis,Camille Hamula,Kristin W. Delli Carpini,Barbara E. Murray,Andrew Kasarskis,Harm van Bakel,Shirish Huprikar +16 more
TL;DR: Comparison of de novo assembled isolate genomes was highly suggestive of transplant transmission rather than hospital-acquired transmission and also identified subtle internal rearrangements between donor and recipient missed by other genomic approaches.
Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia.
Kieran I. Chacko,Mitchell J. Sullivan,Colleen Beckford,Deena R. Altman,Brianne Ciferri,Theodore R. Pak,Robert Sebra,Andrew Kasarskis,Camille Hamula,Harm van Bakel +9 more
TL;DR: Whole-genome sequencing was used to examine a persistent Enterococcus faecium bacteremia that acquired heteroresistance to three antibiotics in response to prolonged multidrug therapy and suggested that a novel mutation in fabF, encoding a fatty acid synthase, was responsible for daptomycin nonsusceptibility.
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MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation.
Sophie Dyzenhaus,Mitchell J. Sullivan,Bremy Alburquerque,Daiane Boff,Adriana van de Guchte,Marilyn Chung,Yi Fulmer,Richard Copin,Juliana K Ilmain,Anna O’Keefe,Deena R. Altman,François-Xavier Stubbe,Magdalena Podkowik,Amy C. Dupper,Bo Shopsin,Harm van Bakel,Victor J. Torres +16 more
TL;DR: In this article , the authors found that repeated and independent mutations in the transcriptional regulator sarZ resulted in increased virulence of USA300 BSI isolates in a murine model of BSI.
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A complete genome screening program of clinical methicillin-resistant Staphylococcus aureus isolates identifies the origin and progression of a neonatal intensive care unit outbreak
Mitchell J. Sullivan,Deena R. Altman,Kieran I. Chacko,Brianne Ciferri,Elizabeth Webster,Theodore R. Pak,Gintaras Deikus,Martha Lewis-Sandari,Zenab Khan,Colleen Beckford,Angela Rendo,Flora Samaroo,Robert Sebra,Ramona Karam-Howlin,Tanis C. Dingle,Camille Hamula,Ali Bashir,Eric E. Schadt,Gopi Patel,Frances Wallach,Andrew Kasarskis,Kathleen Gibbs,Harm van Bakel +22 more
TL;DR: The findings demonstrate the utility of long-read sequencing for hospital surveillance and for characterizing accessory genomic elements that may impact MRSA virulence and persistence.
20
PathoSPOT genomic epidemiology reveals under-the-radar nosocomial outbreaks
Ana Berbel Caban,Theodore R. Pak,Ajay Obla,Amy C. Dupper,Kieran I. Chacko,Lindsey Fox,Alexandra Mills,Brianne Ciferri,Irina Oussenko,Colleen Beckford,Marilyn Chung,Robert Sebra,Melissa Smith,Sarah Conolly,Gopi Patel,Gopi Patel,Andrew Kasarskis,Mitchell J. Sullivan,Deena R. Altman,Harm van Bakel +19 more
TL;DR: It is demonstrated that PathoSPOT genomic surveillance enables the detection of complex transmission chains that are not readily apparent from epidemiological data and that contribute significantly to morbidity and mortality, enabling more effective intervention strategies.