Deena R. Altman
Icahn School of Medicine at Mount Sinai
41 Papers
103 Citations
Deena R. Altman is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Methicillin-resistant Staphylococcus aureus. The author has an hindex of 16, co-authored 30 publications. Previous affiliations of Deena R. Altman include Washington University in St. Louis.
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Papers
Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection.
Deena R. Altman,Mitchell J. Sullivan,Kieran I. Chacko,Divya Balasubramanian,Theodore R. Pak,William E. Sause,Krishan Kumar,Robert Sebra,Gintaras Deikus,Oliver Attie,Hannah R. Rose,Martha J. Lewis,Yi Fulmer,Ali Bashir,Andrew Kasarskis,Eric E. Schadt,Anthony R. Richardson,Victor J. Torres,Bo Shopsin,Harm van Bakel +19 more
TL;DR: It is reported that events associated with agr inactivation result in agr-defective blood and nares strain pairs that are enriched in mutations compared to pairs from wild-type controls, and additional mutations outside the agr locus can contribute to diversification and adaptation during infection by S. aureus agr mutants associated with poor patient outcomes.
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Transmission of methicillin-resistant Staphylococcus aureus via deceased donor liver transplantation confirmed by whole genome sequencing.
Deena R. Altman,Robert Sebra,Jonathan Hand,Oliver Attie,Gintaras Deikus,Kristin W. Delli Carpini,Gopi Patel,M. Rana,A. Arvelakis,P. Grewal,Jayeeta Dutta,Hannah R. Rose,Bo Shopsin,Simon Daefler,Eric E. Schadt,Andrew Kasarskis,H. van Bakel,Ali Bashir,Shirish Huprikar +18 more
TL;DR: It is proposed that similar application of WGS techniques to future investigations of donor bacterial transmission would strengthen the definition of proven bacterial transmission in SOT, particularly in the presence of highly clonal bacteria such as MRSA.
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Mpox vaccine and infection-driven human immune signatures: an immunological analysis of an observational study.
Nathan Bloom,Gianna Cai,Jordan J. Clark,Alison Tarke,Maria Bermudez-Gonzalez,Deena R. Altman,Luz Amarilis Lugo,Francisco Pereira Lobo,Wenlin Ren,Lili Qin,Jennifer L. Yates,Danielle Hunt,William T. Lee,Shane Crotty,Florian Krammer,Alba Grifoni,Alessandro Sette,Viviana Simon,Camila H. Coelho +18 more
- 17 Jul 2023
TL;DR: Infection with monkeypox virus resulted in robust B-cell and T- cell responses, whereas immunisation with JYNNEOS elicited more robust T-cell responses, which can help to inform vaccine design and policies for preventing mpox in humans.
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Hyperglycemia is Associated With Increased Mortality in Critically Ill Patients With COVID-19.
Alon Yehuda Mazori,Ilana Bass,Lili Chan,Kusum S. Mathews,Deena R. Altman,Aparna Saha,Howard Soh,Huei Hsun Wen,Sonali Bose,Emily Leven,Jing Gennie Wang,Gohar Mosoyan,Pattharawin Pattharanitima,Giampaolo Greco,Emily J. Gallagher +14 more
TL;DR: In this paper, the authors explore the relationship between hyperglycemia in the presence and absence of diabetes mellitus and adverse outcomes in critically ill patients with coronavirus disease 2019 (COVID-19).
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Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection
Deena R. Altman,Mitchell J. Sullivan,Kieran I. Chacko,Divya Balasubramanian,Theodore R. Pak,William E. Sause,Krishan Kumar,Robert Sebra,Gintaras Deikus,Oliver Attie,Hannah R. Rose,Martha Lewis,Yi Fulmer,Ali Bashir,Andrew Kasarskis,Eric E. Schadt,Anthony R. Richardson,Victor J. Torres,Bo Shopsin,Harm van Bakel +19 more
TL;DR: It is reported that events associated with agr inactivation result in agr-defective blood and nares strain pairs that are enriched in mutations compared to pairs from wild-type controls, and additional mutations outside the agr locus can contribute to diversification and adaptation during infection by S. aureus agr mutants associated with poor patient outcomes.
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