Deena R. Altman
Icahn School of Medicine at Mount Sinai
41 Papers
103 Citations
Deena R. Altman is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Methicillin-resistant Staphylococcus aureus. The author has an hindex of 16, co-authored 30 publications. Previous affiliations of Deena R. Altman include Washington University in St. Louis.
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Papers
Robust neutralizing antibodies to SARS-CoV-2 infection persist for months.
Ania Wajnberg,Fatima Amanat,Adolfo Firpo,Deena R. Altman,Mark J. Bailey,Mayce Mansour,Meagan McMahon,Philip Meade,Damodara Rao Mendu,Kimberly Muellers,Daniel Stadlbauer,Kimberly Stone,Shirin Strohmeier,Viviana Simon,Judith A. Aberg,David Reich,Florian Krammer,Carlos Cordon-Cardo +17 more
TL;DR: The vast majority of infected individuals with mild-to-moderate COVID-19 experience robust immunoglobulin G antibody responses against the viral spike protein, and titers are relatively stable for at least a period of about 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2.
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Convalescent plasma treatment of severe COVID-19: a propensity score-matched control study.
Sean T. H. Liu,Hung-Mo Lin,Ian Baine,Ania Wajnberg,Jeffrey P. Gumprecht,Farah Rahman,Denise Rodriguez,Pranai Tandon,Adel Bassily-Marcus,Jeffrey Bander,Charles Sanky,Amy C. Dupper,Allen Zheng,Freddy T. Nguyen,Fatima Amanat,Daniel Stadlbauer,Deena R. Altman,Benjamin K. Chen,Florian Krammer,Damodara Rao Mendu,Adolfo Firpo-Betancourt,Matthew A. Levin,Emilia Bagiella,Arturo Casadevall,Carlos Cordon-Cardo,Jeffrey S. Jhang,Suzanne Arinsburg,David Reich,Judith A. Aberg,Nicole M. Bouvier +29 more
TL;DR: Convalescent plasma is potentially effective against COVID-19, but adequately powered, randomized controlled trials are needed.
Introductions and early spread of SARS-CoV-2 in the New York City area
Ana S. Gonzalez-Reiche,Matthew M. Hernandez,Mitchell J. Sullivan,Brianne Ciferri,Hala Alshammary,Ajay Obla,Shelcie Fabre,Giulio Kleiner,Jose Polanco,Zenab Khan,Bremy Alburquerque,Adriana van de Guchte,Jayeeta Dutta,Nancy Francoeur,Betsaida Salom Melo,Irina Oussenko,Gintaras Deikus,Juan C. Diaz Soto,Shwetha Hara Sridhar,Ying-Chih Wang,Kathryn Twyman,Andrew Kasarskis,Deena R. Altman,Melissa Smith,Robert Sebra,Judith A. Aberg,Florian Krammer,Adolfo Garcia-Sarstre,Marta Luksza,Gopi Patel,Alberto Paniz-Mondolfi,Melissa R. Gitman,Emilia Mia Sordillo,Viviana Simon,Harm van Bakel +34 more
TL;DR: Phylogenetic analysis of 84 distinct SARS-CoV2 genomes indicates multiple, independent but isolated introductions mainly from Europe and other parts of the United States.
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Mutations in agr do not persist in natural populations of methicillin-resistant Staphylococcus aureus.
Bo Shopsin,Christian Eaton,Gregory A. Wasserman,Barun Mathema,Rajan P. Adhikari,Simon Agolory,Deena R. Altman,Robert S. Holzman,Barry N. Kreiswirth,Richard P. Novick +9 more
TL;DR: The results suggest that agr dysfunction is adaptive for survival in the infected host but that it may be counteradaptive outside infected host tissues.
Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis.
Pedro H. Oliveira,John W. Ribis,Elizabeth M. Garrett,Dominika Trzilova,Alex Kim,Ognjen Sekulovic,Edward A. Mead,Theodore R. Pak,Shijia Zhu,Gintaras Deikus,Marie Touchon,Marie Touchon,Martha Lewis-Sandari,Colleen Beckford,Nathalie E. Zeitouni,Deena R. Altman,Elizabeth Webster,Irina Oussenko,Supinda Bunyavanich,Aneel K. Aggarwal,Ali Bashir,Gopi Patel,Frances Wallach,Camille Hamula,Shirish Huprikar,Eric E. Schadt,Robert Sebra,Harm van Bakel,Andrew Kasarskis,Rita Tamayo,Aimee Shen,Gang Fang +31 more
TL;DR: A comprehensive DNA methylome analysis of C. difficile using 36 human isolates finds an orphan DNA methyltransferase with a well-defined specificity and a set of methods for comparative epigenomics and integrative analysis, which are broadly applicable to bacterial epigenomic studies.