Dedra Harmody
Harbor Branch Oceanographic Institute
19 Papers
236 Citations
Dedra Harmody is an academic researcher from Harbor Branch Oceanographic Institute. The author has contributed to research in topics: Cytotoxicity & Chemistry. The author has an hindex of 13, co-authored 17 publications.
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Papers
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
Amy E. Wright,Julianne Cook Botelho,Esther A. Guzmán,Dedra Harmody,Patricia Linley,Peter J. McCarthy,Tara P. Pitts,Shirley A. Pomponi,John K. Reed +8 more
TL;DR: Neopeltolide is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively.
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A molecular systematic survey of cultured microbial associates of deep-water marine invertebrates
Karen S. Sfanos,Dedra Harmody,Phat M. Dang,Angela Ledger,Shirley A. Pomponi,Peter J. McCarthy,Jose V. Lopez +6 more
TL;DR: A taxonomic survey was conducted to determine the microbial diversity held within the Harbor Branch Oceanographic Marine Microbial Culture Collection (HBMMCC), indicating the likely discovery of novel microbial taxa.
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Discodermolide--a new, marine-derived immunosuppressive compound. I. In vitro studies.
TL;DR: In vitro immunosuppressive properties of a novel, marine-derived compound, discodermolide, are reported here and the percentage of IL-2 receptor-bearing cells as measured by immunofluorescence with 7D4 antibody, specific for the 55-kDa chain (p55) comprising the murine IL- 2 receptor, was reduced.
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Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.
TL;DR: Twenty-four metabolites derived from marine sponges were evaluated for their cytotoxicities against two human tumor cell lines, non-small cell lung carcinoma A549 and colon adenocarcinoma HT-29, and against one murine leukemia cell line, P-388, and evaluation for their ability to effect signal transduction in a newly developed cell adhesion assay using an EL-4 cell line.
112
The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells
Esther A. Guzmán,Kelly Maers,Jill C. Roberts,Hilaire V. Kemami-Wangun,Dedra Harmody,Amy E. Wright +5 more
TL;DR: Treatment of AsPC-1 cells with microsclerodermin A resulted in an increase in IL-8 production without apparent induction of angiogenic factors and there is the possibility that inhibition of NFκB by micro sclerodermine A is mediated by the glycogen synthase kinase 3β pathway.
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