Debra G.B. Leonard
University of Vermont
100 Papers
1.6K Citations
Debra G.B. Leonard is an academic researcher from University of Vermont. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 41, co-authored 96 publications. Previous affiliations of Debra G.B. Leonard include NewYork–Presbyterian Hospital & Harvard University.
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Papers
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
Catherine S. Manno,Glenn F. Pierce,Valder R. Arruda,Bertil Glader,Margaret V. Ragni,Rasko Jj,Margareth C. Ozelo,Keith Hoots,Blatt P,Barbara A. Konkle,Michael D. Dake,Robin D. Kaye,Mahmood K. Razavi,A Zajko,James L. Zehnder,Pradip Rustagi,Hiroyuki Nakai,A Chew,Debra G.B. Leonard,Debra G.B. Leonard,J F Wright,Ruth Lessard,Jurg M. Sommer,Michael Tigges,Denise E. Sabatino,A Luk,Haiyan Jiang,Federico Mingozzi,Linda B. Couto,Hildegund C.J. Ertl,Katherine A. High,Katherine A. High,Mark A. Kay +32 more
TL;DR: In this article, a single portal vein infusion of a recombinant adeno-associated viral vector (rAAV) expressing canine Factor IX (F.IX) resulted in long-term expression of therapeutic levels of F.IX in dogs with severe hemophilia B.
2.1K
AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.
Catherine S. Manno,Amy J. Chew,Sylvia Hutchison,Peter J. Larson,Roland W. Herzog,Valder R. Arruda,Shing Jen Tai,Margaret V. Ragni,Arthur A. Thompson,Margareth C. Ozelo,Linda B. Couto,Debra G.B. Leonard,Fred Johnson,Alan McClelland,Ciaran Scallan,Erik D. Skarsgard,Alan W. Flake,Mark A. Kay,Katherine A. High,Bertil Glader +19 more
TL;DR: Results of the first parenteral administration of rAAV demonstrate that administration of AAV vector by the intramuscular route is safe at the doses tested and effects gene transfer and expression in humans in a manner similar to that seen in animals.
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Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.
Susan A. Veals,Chris Schindler,Debra G.B. Leonard,Xin-Yuan Fu,Ruedi Aebersold,James E. Darnell,David E. Levy +6 more
TL;DR: Sequencing of ISGF3 gamma cDNA clones revealed significant similarity to the interferon regulatory factor (IRF) family of DNA binding proteins in the amino-terminal 117 residues of IS GF3 gamma, suggesting that other IRF family members may participate in signaling pathways by interacting with as yet unidentified regulatory subunits analogous toISGF3 alpha.
414
College of American pathologists' laboratory standards for next-generation sequencing clinical tests
Nazneen Aziz,Qin Zhao,Lynn Bry,Denise K. Driscoll,Birgit Funke,Jane Gibson,Wayne W. Grody,Madhuri Hegde,Gerald A. Hoeltge,Debra G.B. Leonard,Jason D. Merker,Rakesh Nagarajan,Linda A. Palicki,Ryan S. Robetorye,Iris Schrijver,Karen E. Weck,Karl V. Voelkerding +16 more
TL;DR: This report describes the important issues considered by the CAP committee during the development of the new checklist requirements, which address documentation, validation, quality assurance, confirmatory testing, exception logs, monitoring of upgrades, variant interpretation and reporting, incidental findings, data storage, version traceability and data transfer confidentiality.
Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells
TL;DR: It is suggested that the NGF-regulated mRNAs may play roles in the establishment of the neuronal phenotype and that the probes described here will be useful to study the mechanism of action of NGF and the development and differentiation of neurons.
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