Deborah Pre
Discovery Institute
20 Papers
46 Citations
Deborah Pre is an academic researcher from Discovery Institute. The author has contributed to research in topics: Induced pluripotent stem cell & Biology. The author has an hindex of 9, co-authored 17 publications. Previous affiliations of Deborah Pre include Sanford-Burnham Institute for Medical Research & University of Pavia.
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Papers
Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.
Andrew A. Sproul,Samson T. Jacob,Deborah Pre,Soong Ho Kim,Michael W. Nestor,Miriam Navarro-Sobrino,Ismael Santa-Maria,Matthew Zimmer,Soline Aubry,John W. Steele,David J. Kahler,Alex Dranovsky,Ottavio Arancio,John F. Crary,Sam Gandy,Scott Noggle +15 more
TL;DR: In this model, induced pluripotent stem cells from affected and unaffected individuals from two families carrying PSEN1 mutations are generated and an essential feature in the molecular pathogenesis of FAD is reconstituted, increased generation of Aβ42/40, and has characterized novel expression changes.
Low-amplitude high frequency vibration down-regulates myostatin and atrogin-1 expression, two components of the atrophy pathway in muscle cells
Gabriele Ceccarelli,Laura Benedetti,Daniela Galli,Deborah Pre,Giulia Silvani,Nicola Crosetto,Giovanni Magenes,Maria Gabriella Cusella De Angelis +7 more
TL;DR: It is concluded that vibration treatment at 30 Hz is effective in suppressing the atrophy pathway both in vivo and in vitro and enhances fusion of satellite muscle cells.
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Effects of low-amplitude, high-frequency vibrations on proliferation and differentiation of SAOS-2 human osteogenic cell line.
Deborah Pre,Gabriele Ceccarelli,Laura Benedetti,Giovanni Magenes,Maria Gabriella Cusella De Angelis +4 more
TL;DR: A strong increase in the expression of the genes involved in tissue differentiation in the treated groups with respect to the controls is suggested and the proliferation seems to be slowed down, so probably the acceleration perceived by the mechanosensors of the cells changes the cellular cycle.
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Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies
Michael W. Nestor,Samson T. Jacob,Bruce Sun,Deborah Pre,Andrew A. Sproul,Seong Im Hong,Chris M. Woodard,Matthew Zimmer,Vorapin Chinchalongporn,Vorapin Chinchalongporn,Ottavio Arancio,Scott Noggle +11 more
TL;DR: Using serum-free embryoid bodies generated from human inducible pluripotent stem cells (iPSCs), it is demonstrated that these interneuron progenitors exhibit morphological, immunocytochemical, and electrophysiological hallmarks of developing cortical interneurons.
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Connectivity and circuitry in a dish versus in a brain.
Vorapin Chinchalongporn,Peter Koppensteiner,Deborah Pre,Wipawan Thangnipon,Leonilda Bilo,Ottavio Arancio +5 more
TL;DR: There are still many hurdles to overcome before human induced pluripotent stem cell-derived neurons can fully recapitulate all of the above physiological properties of adult mature neurons, but in vitro neuronal stemcell-derived models hold great promise for clinical application in neurological diseases in the future.