Deborah P M Symmons
University of Manchester
457 Papers
3.7K Citations
Deborah P M Symmons is an academic researcher from University of Manchester. The author has contributed to research in topics: Rheumatoid arthritis & Medicine. The author has an hindex of 106, co-authored 446 publications. Previous affiliations of Deborah P M Symmons include Norfolk and Norwich University Hospital & University of Birmingham.
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Papers
Infection rates in patients from five rheumatoid arthritis (RA) registries: contextualising an RA clinical trial programme.
Hisashi Yamanaka,Johan Askling,Niklas Berglind,Stefan Franzén,Thomas Frisell,Christopher Garwood,Jeff Greenberg,Meilien Ho,Marie Holmqvist,Laura Horne,Eisuke Inoue,Kaleb Michaud,Dimitrios A. Pappas,George W. Reed,Deborah P M Symmons,Deborah P M Symmons,Eiichi Tanaka,Trung N. Tran,Suzanne M M Verstappen,Eveline Wesby-van Swaay,Fredrik Nyberg,Fredrik Nyberg +21 more
TL;DR: This prospective, coordinated analysis of RA registries provided incidence rate estimates for infection events to contextualise infection rates from an RA clinical trial programme and demonstrated relative comparability of hospitalised infection rates across registries.
Macrophage migration inhibitory factor (MIF) gene polymorphism is associated with susceptibility to but not severity of inflammatory polyarthritis
Anne Barton,Rebecca Lamb,Deborah P M Symmons,Alan J. Silman,Wendy Thomson,Jane Worthington,Rachelle Donn +6 more
TL;DR: MIF is a susceptibility gene for the development of IP, and the same alleles previously reported to be associated with susceptibility to juvenile idiopathic arthritis account for the increased risk.
•Journal Article
Low prevalence of rheumatoid arthritis in the urbanized Chinese of Hong Kong.
Edith M. C. Lau,Deborah P M Symmons,Clare Bankhead,Alex J. MacGregor,S J Donnan,Alan J. Silman +5 more
TL;DR: RA is rare in urbanized Chinese and significantly lower than published data for European Caucasians (standardized morbidity ratio = 0.27; 95% CI 0.09-0.63).
Estimating the incidence of rheumatoid arthritis: Trying to hit a moving target?
Nicola J Wiles,Deborah P M Symmons,B. J. Harrison,E M Barrett,Jennifer H. Barrett,David G. I. Scott,Alan J. Silman +6 more
TL;DR: Accurate estimation of the incidence of RA requires long-term followup of patients who present with undifferentiated inflammatory polyarthritis, and the highest age-adjusted estimates from this study are probably the best that are available.
Influence of disease-modifying therapy on radiographic outcome in inflammatory polyarthritis at five years: results from a large observational inception study
Marwan Bukhari,Nicola J Wiles,Mark Lunt,B. J. Harrison,Dgi Scott,Deborah P M Symmons,Alan J. Silman +6 more
TL;DR: DMARD treatment was a marker not only of worse disease at presentation but also of the radiographic state and radiographic progression at 5 years, and earlier therapy was shown to have a beneficial effect on outcome.