Deborah P M Symmons
University of Manchester
457 Papers
3.7K Citations
Deborah P M Symmons is an academic researcher from University of Manchester. The author has contributed to research in topics: Rheumatoid arthritis & Medicine. The author has an hindex of 106, co-authored 446 publications. Previous affiliations of Deborah P M Symmons include Norfolk and Norwich University Hospital & University of Birmingham.
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Papers
Has the Severity of Rheumatoid Arthritis at Presentation Diminished Over Time
Janet Diffin,Mark Lunt,Tarnya Marshall,Jacqueline Chipping,Deborah P M Symmons,Suzanne M M Verstappen +5 more
TL;DR: While baseline disease activity has lessened slightly over time, there has been no improvement in baseline levels of functional disability.
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Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis.
Sebastien Viatte,James Lee,Bo Fu,Marion Espéli,Mark Lunt,Jack N. E. De Wolf,Lily Wheeler,John A. Reynolds,Madhura Castelino,Deborah P M Symmons,Paul A. Lyons,Anne Barton,Kenneth G. C. Smith +12 more
TL;DR: In this paper, the contribution of FoxO3 to prognosis in RA by combining detailed analysis of nonradiographic disease severity measures with an in vivo model of arthritis was investigated.
•Journal Article
Sulfasalazine treatment and lymphocyte function in patients with rheumatoid arthritis.
TL;DR: An in vitro study investigated the effect of sulfasalazine and its metabolites on mitogen response by healthy and RA peripheral blood mononuclear cells (PBMC) and found that 5-aminosalicylic acid affectedMitogen response and cell viability, which may be relevant to actions of this metabolite within the gut.
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HLA-DRB1 Amino Acid Positions 11/13, 71, and 74 Are Associated With Inflammation Level, Disease Activity, and the Health Assessment Questionnaire Score in Patients With Inflammatory Polyarthritis.
Stephanie Ling,Sebastien Viatte,Mark Lunt,Alper M. Van Sijl,Lucía Silva-Fernández,Deborah P M Symmons,Adam Young,Alex J. MacGregor,Anne Barton +8 more
TL;DR: Rheumatoid arthritis (RA) susceptibility HLA–DRB1 haplotypes based on amino acid positions 11/13, 71, and 74 predict radiographic damage.
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Drug-specific risk and characteristics of lupus and vasculitis-like events in patients with rheumatoid arthritis treated with TNFi: results from BSRBR-RA
Meghna Jani,William G Dixon,Lianne Kersley-Fleet,Ian N. Bruce,Hector Chinoy,Anne Barton,Mark Lunt,Kath D. Watson,Bsrbr-Ra,Deborah P M Symmons,Kimme L. Hyrich +10 more
TL;DR: In this paper, the authors compared the risk of lupus-like events (LLEs) and vasculitis-like event (VLEs), in tumour necrosis factor-α inhibitor (TNFi)-treated patients with rheumatoid arthritis (RA) to those receiving non-biological disease-modifying antirheumatic drugs (nbDMARDs).
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