Deborah E. Murphy
Novartis
10 Papers
454 Citations
Deborah E. Murphy is an academic researcher from Novartis. The author has contributed to research in topics: NMDA receptor & Ligand (biochemistry). The author has an hindex of 9, co-authored 10 publications.
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Papers
•Journal Article
CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.
John Lehmann,J Schneider,S E McPherson,Deborah E. Murphy,P S Bernard,C Tsai,Debra A. Bennett,G Pastor,D J Steel,C Boehm +9 more
TL;DR: In conclusion, based upon the competitive antagonism by CPP of NMDA-evoked [3H] ACh release in vitro and the antagonism ofNMDA-induced convulsions in vivo, the data presented are consistent with competitive antagonisms of NMda-type receptors.
252
•Journal Article
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
John Lehmann,Hutchison Alan J,S E McPherson,C Mondadori,Markus Schmutz,C M Sinton,C Tsai,Deborah E. Murphy,D J Steel,Michael Williams +9 more
TL;DR: CGS 19755 (cis-4-phosphonomethyl-2-piperidine carboxylic acid) was found to be a potent, stereospecific inhibitor of N-methyl-D-aspartate (NMDA)-evokes, but not KCl-evoked, [3H] acetylcholine release from slices of the rat striatum, suggesting a competitive interaction with NMDA-type receptors.
231
•Journal Article
Binding of [3H]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to rat brain membranes: a selective, high-affinity ligand for N-methyl-D-aspartate receptors
TL;DR: CPP binding was stereoselective for the isomers of glutamate, 2-amino-5-phosphonopentanoic acid, homocysteic acid and N-methyl-aspartate, and the most potent compounds tested were L-glutamate and CPP, which were equiactive in displacing [3H]CPP.
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Characterization of the binding of [3H]-CGS 19755: a novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain.
TL;DR: The high affinity binding obtained with [3H]‐CGS 19755 by use of filtration techniques permits the more rapid evaluation of compounds as potential NMDA antagonists and agonists.
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Characterization of quisqualate recognition sites in rat brain tissue using DL-[3H]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and a filtration assay.
TL;DR: The present technique provides a rapid, reliable assay for the evaluation of quisqualate-type excitatory amino acid agonists and/or antagonists that may be used to discover more potent and selective agents.
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