Deborah E. Crawford

TL;DR: In this paper, the potential of twin screw extrusion for organic synthesis was highlighted by reporting four condensation reactions, the Knoevenagel condensation, imine formation, aldol reaction and the Michael addition, most of which did not require any post synthetic purification or isolation.

TL;DR: Mechanochemical synthesis has been applied to the rapid synthesis of Deep Eutectic Solvents, including Reline 200, in a continuous flow methodology by Twin Screw Extrusion (TSE), which gave products in higher purity and with Space Time Yields (STYs), four orders of magnitude greater than for batch methods.

TL;DR: The synthesis of metal-organic frameworks (MOFs) is highlighted herein as an excellent example showcasing the advantages that extrusion provides to the manufacture of these materials, one advantage being the exceptional space time yields (STYs) reported for these processes, at three orders of magnitude greater than conventional (solvothermal) synthesis.

TL;DR: In this paper, the authors discuss opportunities offered and challenges laying ahead for the adoption of mechanochemical manufacturing technologies into industry, and propose a new research space full of opportunities for mechanochemical research.