Deborah A. Ledesma
University of Texas MD Anderson Cancer Center
4 Papers
Deborah A. Ledesma is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Immune system & Immunology. The author has an hindex of 1, co-authored 1 publications.
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Papers
B cells and tertiary lymphoid structures promote immunotherapy response
Beth A. Helmink,Sangeetha M. Reddy,Jianjun Gao,Shaojun Zhang,Rafet Basar,Rohit Thakur,Keren Yizhak,Moshe Sade-Feldman,Moshe Sade-Feldman,Jorge Blando,Guangchun Han,Vancheswaran Gopalakrishnan,Yuanxin Xi,Hao Zhao,Rodabe N. Amaria,Hussein Abdul-Hassan Tawbi,Alex P. Cogdill,Wenbin Liu,Valerie S. LeBleu,Fernanda G. Kugeratski,Sapna Pradyuman Patel,Michael A. Davies,Patrick Hwu,Jeffrey E. Lee,Jeffrey E. Gershenwald,Anthony Lucci,Reetakshi Arora,Scott E. Woodman,Emily Z. Keung,Pierre Olivier Gaudreau,Alexandre Reuben,Christine N. Spencer,Elizabeth M. Burton,Lauren E. Haydu,Alexander J. Lazar,Roberta Zapassodi,Courtney W. Hudgens,Deborah A. Ledesma,SuFey Ong,Michael Bailey,Sarah Warren,Disha Rao,Oscar Krijgsman,Elisa A. Rozeman,Daniel S. Peeper,Christian U. Blank,Ton N. Schumacher,Lisa H. Butterfield,Monika A. Zelazowska,Kevin M. McBride,Raghu Kalluri,James P. Allison,Florent Petitprez,Florent Petitprez,Wolf H. Fridman,Wolf H. Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Nir Hacohen,Nir Hacohen,Katayoun Rezvani,Padmanee Sharma,Michael T. Tetzlaff,Linghua Wang,Jennifer A. Wargo +64 more
TL;DR: B cell markers were the most differentially expressed genes in the tumours of responders versus non-responders and insights are provided into the potential role of B cells and tertiary lymphoid structures in the response to ICB treatment, with implications for the development of biomarkers and therapeutic targets.
Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration
Yifan Zhou,Yusra Medik,Bhakti Patel,Daniel Zamler,Sijie Chen,T. Chapman,Sarah Schneider,Rachel L. Babcock,Taylor T. Chrisikos,Laura Maria S. Kahn,Allison Dyevoich,Elizabeth M. Park,Alexandria P. Cogdill,Daniel H. Johnson,Sarah B. Johnson,Khalida Wani,Deborah A. Ledesma,Courtney W. Hudgens,Jingjing Wang,Abdul Wadud Khan,Aron Y. Joon,Weiyi Peng,Haiyan S. Li,Reetakshi Arora,Ximing Tang,Maria Gabriela Raso,Xuegong Zhang,Wai Chin Foo,Michael T. Tetzlaff,Gretchen E. Diehl,Karen Clise-Dwyer,Elizabeth M. Whitley,Matthew M. Gubin,James P. Allison,Patrick Hwu,Nadim J. Ajami,Adi Diab,Jennifer A. Wargo,Stephanie S. Watowich +38 more
TL;DR: Animal models of intestinal irAE show that disruption of homeostatic immunity by genetic predisposition to intestinal inflammation or acute gastrointestinal infection sensitizes mice to anti-CTLA-4-mediated intestinal toxicity.
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Differential Upregulation of Th1/Th17-Associated Proteins and PD-L1 in Granulomatous Mycosis Fungoides
Mario L. Marques-Piubelli,Jesus Navarrete,Deborah A. Ledesma,Courtney W. Hudgens,Rossana Lazcano,Ali Alani,Auris Huen,Madeleine Duvic,Priyadharsini Nagarajan,Phyu P Aung,Ignacio I. Wistuba,Jonathan L. Curry,Roberto N. Miranda,Carlos A. Torres-Cabala +13 more
TL;DR: GMF exhibits a Th1/Th17-associated protein expression profile and increased PD-L1 expression.
Cellular and Molecular Mechanisms of Liver Fibrosis in Patients with NAFLD
Jessica I. Sanchez,Edwin R. Parra,Jingjing Jiao,Luisa M. Solis Soto,Deborah A. Ledesma,Omar A. Saldarriaga,Heather L. Stevenson,Laura Beretta +7 more
TL;DR: In this paper , the expression of immune and cancer-related genes was measured in liver biopsies from 107 nonalcoholic fatty liver disease patients and the strongest difference in overall gene expression was between liver fibrosis stages F3 and F4, with 162 cirrhosis-associated genes identified.