Debbie Padilla
4 Papers
Debbie Padilla is an academic researcher. The author has contributed to research in topics: PfSPZ vaccine & Plasmodium falciparum. The author has an hindex of 4, co-authored 4 publications.
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Papers
Protection against Plasmodium falciparum malaria by PfSPZ Vaccine
Judith E. Epstein,Kristopher M. Paolino,Thomas L. Richie,Martha Sedegah,Alexandra Singer,Adam Ruben,Sumana Chakravarty,April Stafford,Richard C. Ruck,Abraham G. Eappen,Tao Li,Peter F. Billingsley,Anita Manoj,Joana C. Silva,Kara A. Moser,Robin Nielsen,Donna Tosh,Susan Cicatelli,Harini Ganeshan,Jessica Case,Debbie Padilla,Silas A. Davidson,Lindsey S. Garver,Elizabeth Saverino,Tooba Murshedkar,Anusha Gunasekera,Patrick S. Twomey,Sharina Reyes,James E. Moon,Eric R. James,Natasha Kc,Minglin Li,Esteban Abot,Arnel Belmonte,Kevin Hauns,Maria Belmonte,Jun Huang,Carlos S. Vasquez,Shon Remich,Mary Carrington,Yonas Abebe,Amy Tillman,Bradley Hickey,Jason A. Regules,Eileen Villasante,B. Kim Lee Sim,Stephen L. Hoffman +46 more
TL;DR: It is demonstrated for the first time to the authors' knowledge that PfSPZ Vaccine can protect against a 3-week heterologous CHMI in a limited group of malaria-naive adult subjects and provides a foundation for developing an optimized immunization regimen for preventing malaria.
SHEKALAGHE AND OTHERS INJECTION OF TANZANIANS WITH P. FALCIPARUM SPOROZOITES Controlled Human Malaria Infection of Tanzanians by Intradermal Injection of Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites
Seif Shekalaghe,Mastidia Rutaihwa,Peter F. Billingsley,Mwajuma Chemba,Eric James,Maximillian Mpina,Omar Juma,Tobias Schindler,Eric Huber,Anusha Gunasekera,Anita Manoj,Beatus Simon,Elizabeth Savarino,L. W. Preston Church,Cornelus C. Hermsen,Robert W. Sauerwein,Christopher V. Plowe,Meera Venkatesan,Omar Lweno,Paul Mutani,Ali Hamad,Ali Mohammed,Alwisa Urassa,Tutu Mzee,Debbie Padilla,Adam Ruben,Bo S. Kim,Lee Sim,Marcel Tanner,Salim Abdullah,Stephen L. Hoffman +30 more
- 01 Jan 2014
TL;DR: Aseptic, purified, cryopreserved Pf sporozoites, PfSPZ Challenge, were used to infect Dutch volunteers by intradermal injection and was safe, well tolerated, and infectious.
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Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites.
Seif Shekalaghe,Mastidia Rutaihwa,Peter F. Billingsley,Mwajuma Chemba,Claudia Daubenberger,Eric R. James,Maximillian Mpina,Omar Juma,Tobias Schindler,Eric Huber,Anusha Gunasekera,Anita Manoj,Beatus Simon,Elizabeth Saverino,L. W. Preston Church,Cornelus C. Hermsen,Robert W. Sauerwein,Christopher V. Plowe,Meera Venkatesan,Philip Sasi,Omar Lweno,Paul Mutani,Ali Hamad,Ali Mohammed,Alwisa Urassa,Tutu Mzee,Debbie Padilla,Adam Ruben,B. Kim Lee Sim,Marcel Tanner,Salim Abdulla,Stephen L. Hoffman +31 more
TL;DR: A double-blind, placebo-controlled trial to assess safety and infectivity of PfSPZ Challenge in adult male Tanzanians was conducted in this paper, where volunteers were injected with 10,000 or 25,000 Pf sporozoites or normal saline.
Robust, reproducible, industrialized, standard membrane feeding assay for assessing the transmission blocking activity of vaccines and drugs against Plasmodium falciparum.
Tao Li,Abraham G. Eappen,Adam Richman,Peter F. Billingsley,Yonas Abebe,Minglin Li,Debbie Padilla,Isabel Rodriguez-Barraquer,B. Kim Lee Sim,Stephen L. Hoffman +9 more
TL;DR: A robust capacity to perform the standard Plasmodium falciparum membrane-feeding assay in a medium-to-high throughput format, suitable for assessing large numbers of experimental samples of candidate antibodies or drugs is demonstrated.