Dean Clift
Laboratory of Molecular Biology
27 Papers
88 Citations
Dean Clift is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 14, co-authored 23 publications. Previous affiliations of Dean Clift include University of Edinburgh.
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Papers
A Method for the Acute and Rapid Degradation of Endogenous Proteins
Dean Clift,William A. McEwan,Larisa I. Labzin,Vera Konieczny,Binyam Mogessie,Leo C. James,Melina Schuh +6 more
TL;DR: Trim-Away harnesses the cellular protein degradation machinery to remove unmodified native proteins within minutes of application, which minimizes the risk that phenotypes are compensated and that secondary, non-specific defects accumulate over time.
437
Restarting life: fertilization and the transition from meiosis to mitosis
Dean Clift,Melina Schuh +1 more
TL;DR: Fertilization triggers a complex cellular programme that transforms two highly specialized meiotic germ cells into a totipotent mitotic embryo.
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.
Tomas Castro-Dopico,Thomas W. Dennison,John R. Ferdinand,Rebeccah J. Mathews,Aaron M. Fleming,Dean Clift,Benjamin J. Stewart,Chenzhi Jing,Konstantina Strongili,Larisa I. Labzin,Edward J.M. Monk,Kourosh Saeb-Parsy,Clare E. Bryant,Simon Clare,Miles Parkes,Menna R. Clatworthy,Menna R. Clatworthy +16 more
TL;DR: A profound induction of anti‐commensal IgG and a concomitant increase in activating Fc&ggr;R signaling in the colonic mucosa of UC patients is found.
179
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.
William A. McEwan,Benjamin Falcon,Marina Vaysburd,Dean Clift,Adrian L. Oblak,Bernardino Ghetti,Michel Goedert,Leo C. James +7 more
TL;DR: In this article, the authors show that when misfolded tau assemblies enter the cell, they can be detected and neutralized via a danger response mediated by tau-associated antibodies and the cytosolic Fc receptor tripartite motif protein 21 (TRIM21).
167
A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes
Dean Clift,Melina Schuh +1 more
TL;DR: This study reveals that mouse oocytes assemble a bipolar spindle by fragmenting multiple acentriolar microtubule-organizing centres (MTOCs) into a high number of small MTOCs to be able to then regroup and merge them into two equal spindle poles.