De Lin
Vanderbilt University
5 Papers
26 Citations
De Lin is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Receptor tyrosine kinase & Proteome. The author has an hindex of 5, co-authored 5 publications.
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Papers
CPTAC Assay Portal: a repository of targeted proteomic assays
Jeffrey R. Whiteaker,Goran N. Halusa,Andrew N. Hoofnagle,Vagisha Sharma,Brendan MacLean,Ping Yan,John A. Wrobel,Jacob J. Kennedy,D. R. Mani,Lisa J. Zimmerman,Matthew R. Meyer,Mehdi Mesri,Henry Rodriguez,Amanda G. Paulovich,Susan E. Abbatiello,Emily S. Boja,Steven A. Carr,Daniel W. Chan,Xian Chen,Jing Chen,Sherri R. Davies,Matthew J. Ellis,David Fenyö,Tara Hiltke,K. A. Ketchum,Christopher R. Kinsinger,Eric Kuhn,Daniel C. Liebler,De Lin,Tao Liu,Michael Loss,Michael J. MacCoss,Wei-Jun Qian,Robert Rivers,Karin D. Rodland,Kelly V. Ruggles,Mitchell G. Scott,Richard D. Smith,Stefani N. Thomas,R. Reid Townsend,Gordon Whiteley,Chaochao Wu,Hui Zhang,Zhen Zhang +43 more
TL;DR: To address these issues, the Clinical Proteomic Tumor Analysis Consortium (CPTAC) of the National Cancer Institute has launched an Assay Portal to serve as a public repository of well-characterized quantitative, MS-based, targeted proteomic assays.
Reversibility of covalent electrophile-protein adducts and chemical toxicity.
TL;DR: The results suggest that low BMCC toxicity reflects facile repair that results in transient adduction, which fails to trigger damage-signaling pathways.
Comparison of Protein Immunoprecipitation-Multiple Reaction Monitoring with ELISA for Assay of Biomarker Candidates in Plasma
TL;DR: IP-MRM with high-quality capture antibodies provides an effective alternative method to ELISA for protein quantitation in biological fluids for colon cancer biomarker candidates.
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Cysteinyl peptide capture for shotgun proteomics: global assessment of chemoselective fractionation.
TL;DR: Isoelectric focusing followed by LC−MS/MS of Cys-peptides significantly expanded proteome coverage in Saccharomyces cerevisiae and in human colon carcinoma RKO cells, and selective enrichment of cysteine-rich, lower abundance proteins was revealed.
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Quantitative Profiling of Protein Tyrosine Kinases in Human Cancer Cell Lines by Multiplexed Parallel Reaction Monitoring Assays
TL;DR: A parallel reaction monitoring-based assay for quantitative profiling of 83 PTKs was developed and observed distinct PTK expression changes that were induced by stimuli, genomic features or drug resistance, which were consistent with previous reports.