de Arriba Af
2 Papers
de Arriba Af is an academic researcher. The author has contributed to research in topics: Chemical synthesis & Chemistry. The author has an hindex of 2, co-authored 2 publications.
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Papers
Synthesis and SAR of a New Series of COX-2-Selective Inhibitors: Pyrazolo[1,5-a]pyrimidines
C. Almansa,de Arriba Af,F. L. Cavalcanti,L. A. Gomez,Agusti Miralles,Manuel Merlos,Julian Garcia-Rafanell,J. Forn +7 more
TL;DR: Modification of the pyrimidine substituents showed that 6,7-disubstitution provided the best activity and led to the identification of 3-(4-fluorophenyl)-6, 7-dimethyl-2-( 4-methylsulfonylphenyl)pyrazolo[1,5-a]pyrimidine (10f) as one of the most potent and selective COX-2 inhibitor in this series.
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Synthesis and Structure−Activity Relationship of a New Series of Potent AT1 Selective Angiotensin II Receptor Antagonists: 5-(Biphenyl-4-ylmethyl)pyrazoles
TL;DR: Compound 14n, a new series of 5-(biphenyl-4-ylmethyl)pyrazoles as potent angiotensin II antagonists, shows high potency both in vitro and in vivo and is selection for clinical evaluation as an antihypertensive agent.
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