Fur die Aufgabe der Lunge — ausreichende Sauerstoffaufnahme und Kohlendioxidabgabe unter Wahrung des Saure-Basen-Status — sind nicht nur die absoluten Grosen der bekannten Faktoren Perfusion, Ventilation und Diffusion von Bedeutung, sondern auch ihre regionale Verteilung, die Distribution. Bereits beim Gesunden sind Ventilation, Perfusion und Diffusion ungleichmasig auf die verschiedenen Lungenabschnitte verteilt. So sind bei aufrechtem Oberkorper unter dem Einflus der Schwerkraft die Alveolen in den basalen Lungenabschnitten kleiner als in den oberen und daher einer starkeren Ausdehnung fahig. Sie leisten bei normaler Atmung einen groseren Beitrag zum Gasaustausch. Mit zunehmender Atemstromstarke wirken sich zusatzlich die Atemwegwiderstande auf die Verteilung aus. Eine weitere Einflusgrose ist die Atemtiefe (Siegel und Potchen, 1973).

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Radiopharmaceuticals for perfusion scanning.

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Radiopharmaceuticals for perfusion scanning.