Davide Sciuscio
7 Papers
6 Citations
Davide Sciuscio is an academic researcher. The author has contributed to research in topics: Inhalation & Nicotine. The author has an hindex of 5, co-authored 7 publications.
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Papers
Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints.
Blaine Phillips,Bjoern Titz,Ulrike Kogel,Danilal Sharma,Patrice Leroy,Yang Xiang,Gregory Vuillaume,Stefan Lebrun,Davide Sciuscio,Jenny Ho,Catherine Nury,Emmanuel Guedj,Ashraf Elamin,Marco Esposito,Subash Krishnan,Walter K. Schlage,Emilija Veljkovic,Nikolai V. Ivanov,Florian Martin,Manuel C. Peitsch,Julia Hoeng,Patrick Vanscheeuwijck +21 more
TL;DR: This study demonstrates how complementary systems toxicology analyses can reveal, even in the absence of observable adverse effects, subtoxic and adaptive responses to pharmacologically active compounds such as nicotine.
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Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells.
Diego Marescotti,Carole Mathis,Vincenzo Belcastro,Patrice Leroy,Stefano Acali,Florian Martin,Remi Dulize,David Bornand,Dariusz Peric,Emmanuel Guedj,Laura Ortega Torres,Matteo Biasioli,Matthieu Fuhrimann,Estela Fernandes,Felix Frauendorfer,Ignacio Gonzalez Suarez,Davide Sciuscio,Nikolai V. Ivanov,Manuel C. Peitsch,Julia Hoeng +19 more
TL;DR: In this paper, a three-step approach combining real-time cellular analysis, phenotypic high-content screening assays, and gene expression analysis was developed and tested in normal human bronchial epithelial cells with 28 flavoring substances commonly used in e-liquid formulations, dissolved individually or as a mixture in a base solution composed of propylene glycol, vegetable glycerin, and 0.6% nicotine.
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Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis
Jenny Ho,Davide Sciuscio,Ulrike Kogel,Bjoern Titz,Patrice Leroy,Gregory Vuillaume,Marja Talikka,Elyette Martin,Pavel Pospisil,Stefan Lebrun,Wenhao Xia,Tom Lee,Yun Xuan Chng,Blaine Phillips,Emilija Veljkovic,Emmanuel Guedj,Yang Xiang,Nikolai V. Ivanov,Manuel C. Peitsch,Julia Hoeng,Patrick Vanscheeuwijck +20 more
TL;DR: The results indicated that the inhalation of an e-liquid containing the mixture of FGRs caused very minimal local and systemic toxic effects, and there were no remarkable clinical (in-life) observations in flavored e- liquid-exposed rats.
Respirable aerosol exposures of nicotine dry powder formulations to in vitro, ex vivo, and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles.
TL;DR: The results showed a very rapid dissolution and absorption of the two nicotine formulations and these results could be highly useful for improving the design and calibration of physiologically based PK models to produce more robust predictions.
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State-of-the-art methods and devices for generation, exposure, and collection of aerosols from e-vapor products:
Stéphanie Boué,Didier Goedertier,Julia Hoeng,Anita R. Iskandar,Arkadiusz K. Kuczaj,Diego Marescotti,Carole Mathis,Anne May,Blaine Phillips,Manuel C. Peitsch,Walter K. Schlage,Davide Sciuscio,Wei Teck Tan,Patrick Vanscheeuwijck +13 more
- 29 Dec 2020
TL;DR: E-vapor products (EVP) have become popular alternatives for cigarette smokers who would otherwise continue to smoke as discussed by the authors, and they have become a popular alternative for smoking cessation.
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