Davide Andrenacci
National Research Council
19 Papers
114 Citations
Davide Andrenacci is an academic researcher from National Research Council. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 10, co-authored 18 publications. Previous affiliations of Davide Andrenacci include University of Bologna.
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Papers
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS.
Elisabetta Mattioli,Davide Andrenacci,Cecilia Garofalo,Sabino Prencipe,Katia Scotlandi,Daniel Remondini,Davide Gentilini,Anna Maria Di Blasio,Sergio Valente,Emanuela Scarano,Lucia Cicchilitti,Giulia Piaggio,Antonello Mai,Giovanna Lattanzi +13 more
TL;DR: In fibroblasts from patients affected by Hutchinson–Gilford progeria, a severe LMNA‐linked syndrome associated with bone resorption, cardiovascular disorders, and premature aging, altered modulation of CDKN1A, encoding p21, upon oxidative stress induction, and accumulation of senescence markers during stress recovery are found.
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The role of transposable elements activity in aging and their possible involvement in laminopathic diseases.
TL;DR: The possible role of the nuclear lamina, a major player in heterochromatin dynamics, in the regulation of transposable element activity and potential implications in laminopathic diseases is discussed.
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Interleukin‐6 neutralization ameliorates symptoms in prematurely aged mice
Stefano Squarzoni,Elisa Schena,Patrizia Sabatelli,Elisabetta Mattioli,Cristina Capanni,Vittoria Cenni,Maria Rosaria D'Apice,Davide Andrenacci,Giuseppe Sarli,Valeria Pellegrino,Anna Festa,Fabio Baruffaldi,Gianluca Storci,Massimiliano Bonafè,Catia Barboni,Mara Sanapo,Anna Zaghini,Giovanna Lattanzi +17 more
TL;DR: Tocilizumab treatment limits the accumulation of progerin, the toxic protein produced in HGPS cells, rescues nuclear envelope and chromatin abnormalities, and attenuates the hyperactivated DNA damage response.
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Specific domains drive VM32E protein distribution and integration in Drosophila eggshell layers.
Davide Andrenacci,Filippo M. Cernilogar,Carlo Taddei,Deborah Rotoli,Valeria Cavaliere,Franco Graziani,Giuseppe Gargiulo +6 more
TL;DR: The highly conserved vitelline membrane domain is implicated in the early interactions with other components and is required for cross-linking VM32E protein in the viteLLine membrane.
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Drosophila vitelline membrane cross-linking requires the fs(1)Nasrat , fs(1)polehole and chorion genes activities
TL;DR: Altered vitelline membrane cross-linking was detected in a mutant of the chorion protein gene Cp36 and in the chOrion amplification mutant fs(1)K1214, suggesting a role of the structural components of chorions layers in the process of viteLLine membrane hardening.
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