39 Papers
211 Citations
David Zahra is an academic researcher from Australian Nuclear Science and Technology Organisation. The author has contributed to research in topics: Biology & Antibody. The author has an hindex of 16, co-authored 35 publications. Previous affiliations of David Zahra include University of New South Wales & Children's Medical Research Institute.
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Papers
Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
Richard B. Banati,Ryan J. Middleton,Ronald Chan,Claire R. Hatty,Winnie Wai-Ying Kam,Candice Quin,Manuel B. Graeber,Arvind Parmar,David Zahra,Paul D. Callaghan,Sandra Fok,Nicholas R. Howell,Marie Gregoire,Alexander M Szabo,Tien Pham,Emma Davis,Guo Jun Liu,Guo Jun Liu +17 more
TL;DR: It is shown that global C57BL/6-Tspotm1GuWu(GuwiyangWurra)-knockout mice are viable with normal growth, lifespan, cholesterol transport, blood pregnenolone concentration, protoporphyrin IX metabolism, fertility and behaviour, and while the activation of microglia after neuronal injury appears to be unimpaired, microglial output is significantly less ATP, suggesting reduced metabolic activity.
Selective, high-contrast detection of syngeneic glioblastoma in vivo.
Richard B. Banati,Paul Wilcox,Ran Xu,Grace Yin,Emily Si,Eric Taeyoung Son,Mauricio Shimizu,R. M. Damian Holsinger,Arvind Parmar,David Zahra,Andrew Arthur,Ryan J. Middleton,Guo Jun Liu,Arnaud Charil,Manuel B. Graeber +14 more
TL;DR: An animal model that allows high-contrast imaging of wild-type glioma cells by positron emission tomography using [18 F]PBR111 using the mitochondrial 18 kDa Translocator Protein (TSPO) combined with the exclusive expression of TSPO makes it possible, for the first time, to unequivocally and with uniquely high biological contrast identify peri-tumoral gliomas cell invasion at preclinical stages in vivo.
Germline-activating mutations in PIK3CD compromise B cell development and function.
Danielle T. Avery,Alisa Kane,Tina Nguyen,Tina Nguyen,Anthony Lau,Anthony Lau,Akira Nguyen,Akira Nguyen,Helen Lenthall,Kathryn Payne,Wei Shi,Wei Shi,Henry Brigden,Elise French,Julia Bier,Julia Bier,Jana R. Hermes,David Zahra,William A. Sewell,William A. Sewell,William A. Sewell,Danyal Butt,Danyal Butt,Michael Elliott,Michael Elliott,Kaan Boztug,Kaan Boztug,Isabelle Meyts,Sharon Choo,Peter Hsu,Melanie Wong,Lucinda J. Berglund,Lucinda J. Berglund,Paul Gray,Michael O'Sullivan,Theresa Cole,Steven M. Holland,Cindy S. Ma,Cindy S. Ma,Christoph Burkhart,Lynn M. Corcoran,Lynn M. Corcoran,Tri Giang Phan,Tri Giang Phan,Robert Brink,Robert Brink,Gulbu Uzel,Elissa K. Deenick,Elissa K. Deenick,Stuart G. Tangye,Stuart G. Tangye +50 more
TL;DR: Key roles for balanced PI3K signaling in B cell development and long-lived humoral immunity and memory are revealed and the validity of treating affected individuals with p110&dgr; inhibitors is established.
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.
Nathan W. Zammit,Nathan W. Zammit,Owen M. Siggs,Owen M. Siggs,Paul Gray,Keisuke Horikawa,David B. Langley,David B. Langley,Stacey N. Walters,Stacey N. Walters,Stephen R. Daley,Stephen R. Daley,Claudia Loetsch,Joanna Warren,Joanna Warren,Jin Yan Yap,Daniele Cultrone,Daniele Cultrone,Amanda J. Russell,Elisabeth K. Malle,Jeanette E. Villanueva,Mark J. Cowley,Mark J. Cowley,Velimir Gayevskiy,Marcel E. Dinger,Marcel E. Dinger,Robert Brink,Robert Brink,David Zahra,David Zahra,Geeta Chaudhri,Gunasegaran Karupiah,Gunasegaran Karupiah,Belinda Whittle,Carla M. Roots,Edward M. Bertram,Michiko Yamada,Yogesh Jeelall,Anselm Enders,Benjamin E. Clifton,Peter D. Mabbitt,Colin J. Jackson,Susan R. Watson,Craig N. Jenne,Craig N. Jenne,Lewis L. Lanier,Tim Wiltshire,Matthew H. Spitzer,Matthew H. Spitzer,Garry P. Nolan,Frank Schmitz,Frank Schmitz,Alan Aderem,Benjamin T. Porebski,Ashley M. Buckle,Derek W. Abbott,John B. Ziegler,Maria E. Craig,Maria E. Craig,Paul Z. Benitez-Aguirre,Juliana Teo,Stuart G. Tangye,Stuart G. Tangye,Cecile King,Cecile King,Melanie Wong,Murray P. Cox,Wilson Phung,Jia Tang,Wendy Sandoval,Ingrid E. Wertz,Daniel Christ,Daniel Christ,Christopher C. Goodnow,Christopher C. Goodnow,Shane T. Grey,Shane T. Grey +76 more
TL;DR: Genetic analyses of anatomically modern humans, extinct Denisovan hominins and mice revealed a TNFAIP3 allelic series with alterations in the encoded immune response inhibitor A20, which lower A20 activity and increase autoinflammatory responses.
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Sv40‐induced immortalization and ras‐transformation of human bronchial epithelial cells
Roger R. Reddel,R. De Silva,Emma L. Duncan,E. M. Rogan,Noel J. Whitaker,David Zahra,Yang Ke,Mary G. McMenamin,Brenda I. Gerwin,Curtis C. Harris +9 more
TL;DR: It is concluded that immortalization is not sufficient for BE cells to be transformed by the EJ‐ras oncogene, and development of ability to cooperate with activated ras in tumorigenic transformation is found.
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