24 Papers
100 Citations
David Wu is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 13, co-authored 19 publications. Previous affiliations of David Wu include National Institutes of Health & University of Virginia.
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Papers
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
David E. Gordon,Joseph Hiatt,Mehdi Bouhaddou,Veronica V. Rezelj,Svenja Ulferts,Hannes Braberg,Alexander S. Jureka,Kirsten Obernier,Jeffrey Z. Guo,Jyoti Batra,Robyn M. Kaake,Andrew R. Weckstein,Tristan W. Owens,Meghna Gupta,Sergei Pourmal,Erron W. Titus,Merve Cakir,Margaret Soucheray,Michael J. McGregor,Zeynep Cakir,Gwendolyn M. Jang,Matthew J. O’Meara,Tia A. Tummino,Ziyang Zhang,Helene Foussard,Ajda Rojc,Yuan Zhou,Dmitry Kuchenov,Ruth Hüttenhain,Jiewei Xu,Manon Eckhardt,Danielle L. Swaney,Jacqueline M. Fabius,Manisha Ummadi,Beril Tutuncuoglu,Ujjwal Rathore,Maya Modak,Paige Haas,Kelsey M. Haas,Zun Zar Chi Naing,Ernst H. Pulido,Ying Shi,Inigo Barrio-Hernandez,Danish Memon,Eirini Petsalaki,Alistair Dunham,Miguel Correa Marrero,David F. Burke,Cassandra Koh,Thomas Vallet,Jesus A. Silvas,Caleigh M. Azumaya,Christian B. Billesbølle,Axel F. Brilot,Melody G. Campbell,Melody G. Campbell,Amy Diallo,Miles Sasha Dickinson,Devan Diwanji,Nadia Herrera,Nick Hoppe,Huong T. Kratochvil,Yanxin Liu,Gregory E. Merz,Michelle Moritz,Henry C. Nguyen,Carlos Nowotny,Cristina Puchades,Alexandrea N. Rizo,Ursula Schulze-Gahmen,Amber M. Smith,Ming Sun,Iris D. Young,Jianhua Zhao,Daniel Asarnow,Justin T Biel,Alisa Bowen,Julian R. Braxton,Jen Chen,Cynthia M. Chio,Un Seng Chio,Ishan Deshpande,Loan Doan,Bryan Faust,Sebastian Flores,Mingliang Jin,Kate Kim,Victor L Lam,Fei Li,Junrui Li,Y. Li,Yang Li,Xi Liu,Megan Lo,Kyle E. Lopez,Arthur Alves de Melo,Frank R. Moss,Phuong Nguyen,Joana Paulino,Komal Ishwar Pawar,Jessica K. Peters,Thomas H. Pospiech,Maliheh Safari,Smriti Sangwan,Kaitlin Schaefer,Paul V. Thomas,Aye C. Thwin,Raphael Trenker,Eric Tse,Tsz Kin Martin Tsui,Feng Wang,Natalie Whitis,Zanlin Yu,Kaihua Zhang,Yang Zhang,Fengbo Zhou,Daniel J. Saltzberg,Anthony J. Hodder,Amber S. M. Shun-Shion,Daniel M. Williams,Kris M. White,Romel Rosales,Thomas Kehrer,Lisa Miorin,Elena Moreno,Arvind H. Patel,Suzannah J. Rihn,Mir M. Khalid,Albert Vallejo-Gracia,Parinaz Fozouni,Parinaz Fozouni,Camille R. Simoneau,Camille R. Simoneau,Theodore L. Roth,David Wu,Mohd Anisul Karim,Maya Ghoussaini,Ian Dunham,Francesco Berardi,Sebastian Weigang,Maxime Chazal,Jisoo Park,James Logue,Marisa McGrath,Stuart Weston,Robert Haupt,C. James Hastie,Matthew Elliott,Fiona Brown,Kerry A. Burness,Elaine Reid,Mark Dorward,Clare Johnson,Stuart G. Wilkinson,Anna Geyer,Daniel M. Giesel,Carla Baillie,Samantha Raggett,Hannah Leech,Rachel Toth,Nicola Goodman,Kathleen C. Keough,Abigail L. Lind,Reyna J. Klesh,Kafi R. Hemphill,Jared Carlson-Stevermer,Jennifer Oki,Kevin Holden,Travis J. Maures,Katherine S. Pollard,Katherine S. Pollard,Andrej Sali,David A. Agard,Yifan Cheng,James S. Fraser,Adam Frost,Natalia Jura,Tanja Kortemme,Aashish Manglik,Daniel R. Southworth,Robert M. Stroud,Dario R. Alessi,Paul Davies,Matthew B. Frieman,Trey Ideker,Carmen Abate,Nolwenn Jouvenet,Nolwenn Jouvenet,Georg Kochs,Brian K. Shoichet,Melanie Ott,Melanie Ott,Massimo Palmarini,Kevan M. Shokat,Adolfo García-Sastre,Jeremy A. Rassen,Robert Grosse,Oren S. Rosenberg,Kliment A. Verba,Christopher F. Basler,Marco Vignuzzi,Andrew A. Peden,Pedro Beltrao,Nevan J. Krogan +203 more
TL;DR: The authors identified shared biology and host-directed drug targets to prioritize therapeutics with potential for rapid deployment against current and future coronavirus outbreaks, and found that individuals with genotypes corresponding to higher soluble IL17RA levels in plasma are at decreased risk of COVID-19 hospitalization.
Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome
Eric G. Meissner,David Wu,Anu Osinusi,Dimitra Bon,Kimmo Virtaneva,Dan E. Sturdevant,Steve F. Porcella,Honghui Wang,Eva Herrmann,John G. McHutchison,Anthony F. Suffredini,Michael A. Polis,Stephen M. Hewitt,Ludmila Prokunina-Olsson,Henry Masur,Anthony S. Fauci,Shyamasundaran Kottilil +16 more
TL;DR: Results suggest that restoration of type I intrahepatic IFN signaling by EOT may facilitate HCV eradication and prevention of relapse upon withdrawal of SOF/RBV.
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies
Theodore L. Roth,P. Jonathan Li,P. Jonathan Li,Franziska Blaeschke,Franziska Blaeschke,Jasper F. Nies,Jasper F. Nies,Ryan Apathy,Ryan Apathy,Cody T. Mowery,Ruby Yu,Ruby Yu,Michelle L.T. Nguyen,Michelle L.T. Nguyen,Youjin V. Lee,Youjin V. Lee,Anna Truong,Anna Truong,Joseph Hiatt,David Wu,David N. Nguyen,Daniel B. Goodman,Daniel B. Goodman,Jeffrey A. Bluestone,Chun Jimmie Ye,Kole T. Roybal,Eric Shifrut,Eric Shifrut,Alexander Marson +28 more
TL;DR: Pooled knockin screening enables parallelized re-writing of endogenous genetic sequences to accelerate discovery of knockin programs for cell therapies, and nominated a novel transforming growth factor β (TGF-β) R2-41BB chimeric receptor that improved solid tumor clearance.
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Dual gene activation and knockout screen reveals directional dependencies in genetic networks.
Michael Boettcher,Ruilin Tian,James Blau,Evan Markegard,Ryan T. Wagner,David Wu,Xiulei Mo,Anne Biton,Anne Biton,Noah Zaitlen,Haian Fu,Frank McCormick,Martin Kampmann,Michael T. McManus +13 more
TL;DR: A directional dependency network is reconstructed for human K562 leukemia cells and the approach allows the determination of directionality in activating genetic interactions and the interaction network connects previously uncharacterized genes to well-studied pathways and identifies targets relevant for therapeutic intervention.
High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails
Brian R. Shy,Vivasvan Vykunta,Alvin Ha,Alexis Talbot,Theodore L. Roth,David N. Nguyen,Wolfgang Pfeifer,Y. Chen,Franziska Blaeschke,Eric Shifrut,Shane Vedova,Murad R. Mamedov,Jing-Yi Chung,Hong Li,Ruby Yu,David Wu,Jeffrey J. Wolf,Thomas R. Martin,Carlos E. Castro,Lumeng Ye,Jonathan H. Esensten,Justin Eyquem,Alexander Marson +22 more
TL;DR: In this article , single-stranded DNA (ssDNA) HDR templates (HDRTs) incorporating CTSs with reduced toxicity were developed to boost knock-in efficiency and yield by an average of around two-to threefold relative to dsDNA CTS.
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