David T. Purtilo
University of Massachusetts Medical School
69 Papers
1.2K Citations
David T. Purtilo is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Epstein–Barr virus & Virus. The author has an hindex of 28, co-authored 69 publications. Previous affiliations of David T. Purtilo include University of Nebraska Medical Center & St Vincent Hospital.
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Papers
Deficient natural killer cell activity in x-linked lymphoproliferative syndrome
TL;DR: The activity of natural killer cells was found to be deficient in 10 of 12 males with X-linked lymphoproliferative syndrome, a life-threatening proliferation of lymphocytes after infection by Epstein-Barr virus, and increased after treatment with interferon in vitro.
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Variable phenotypic expression of an X-linked recessive lymphoproliferative syndrome.
David T. Purtilo,Daniel DeFlorio,Lindsey M. Hutt,Jag Bhawan,James P.S. Yang,Ralph Otto,William H. Edwards +6 more
TL;DR: Investigation of a family with cancer in boys revealed that at least 20 males had the X-linked recessive lymphoproliferative syndrome, and variable phenotypic expression could have resulted from individual differences in the viral dose, duration of exposure and age at which the boys were exposed to the virus.
242
Fatal strongyloidiasis in immunosuppressed patients
TL;DR: Patients with strongyloidiasis who were studied at autopsy had underlying diseases characterized by depressed cell-mediated immunity, including lepromatous leprosy, malignant tumors, protein-calorie malnutrition, burn, radiation, advanced tuberculosis, tertiary syphilis or pancytopenia, indicating inadequate capacity of cell- mediated immunity for preventing Strongyloides stercoralis.
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Epstein-Barr virus-induced diseases in boys with the X-linked lymphoproliferative syndrome (XLP): update on studies of the registry.
David T. Purtilo,Kiyoshi Sakamoto,Vanessa M. Barnabei,Janet Seeley,Thomas Bechtold,Geraldine Rogers,Joanne Yetz,Shinji Harada,Izet Berkel,Carter D. Brooks,George Bucchanan,Robert T. Collins,Frank G. Cruzi,Gerald Z. Finkelstein,Anders Glomstein,J. Greally,Margaret Grunet,Gertrude Henle,Werner Henle,Elvin Kaplan,George Klein,Martin R. Klemperer,Benjamin H. Landing,Sevre Lie,Robert Maier,Helen S. Maurer,Michael Medici,Hans D. Ochs,Lauren M. Pachman,Paul K. Pattengale,Gary R. Pearson,Arthur J. Provisor,Gordon F. Vawter +32 more
TL;DR: Results of immunologic and virologic studies of 15 survivors revealed combined variable immunodeficiency and deficient antibody responses to EBV-specific antigens and mothers of boys with XLP exhibited abnormally elevated titers of antibodies of EBV.
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•Journal Article
The Epstein-Barr virus in the pathogenesis of posttransplant lymphoproliferative disorders. Clinical, pathologic, and virologic correlation.
TL;DR: EBV specific antibody titers, anticomplement immunofluorescence staining of tumors for the presence of the Epstein-Barr nuclear antigen (EBNA), and EBV complementary ribonucleic acid (cRNA)/deoxyribonucleics acid (DNA) hybridization and vDNA/DNA reassociation analysis implicate EBV as the probable etiologic agent in these disorders.
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