David Skerrow
University of Glasgow
8 Papers
305 Citations
David Skerrow is an academic researcher from University of Glasgow. The author has contributed to research in topics: Keratin & Epidermis (botany). The author has an hindex of 7, co-authored 8 publications.
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Papers
Tonofilament differentiation in human epidermis, isolation and polypeptide chain composition of keratinocyte subpopulations.
TL;DR: Analysis of the keratinocyte subpopulations by SDS-PAGE revealed directly their tonofilament chain composition, and it is suggested that synthesis of the Mr 70000 chain in suprabasal keratinocytes is normally linked with their loss of mitotic ability in the skin disease psoriasis.
128
Protein modifications during the keratinization of normal and psoriatic human epidermis
David Skerrow,Irene Hunter +1 more
TL;DR: It is concluded that this is a major, reversible difference between involved psoriatic epidermis and uninvolved psoriatics and that it most probably results from a defect in the synthesis of the alpha-chain.
101
The proteins of living psoriatic epidermis.
L Hunter,David Skerrow +1 more
TL;DR: It has been suggested that, in psoriasis, the deficiency of the 70 kilodalton chain may occur prior to or simultaneously with the induction of increased tissue turnover, and comparisons of amino acid compositions of proteins containing different proportions of 70 Kilodalon chain suggest that it has a considerably higher content of glycine and serine than the other tonofilament chains.
37
The isolation and preliminary characterisation of human prekeratin
TL;DR: A method for isolation of human epidermal prekeratin, using citrate buffer, pH 2.6, is described, which shows that the molecule has three different polypeptide chains of molecular weights 70 000, 63 000 and 55 000 and no interchain disulphide bonds.
23
Dissection of the bovine epidermal desmosome into cytoplasmic protein and membrane glycoprotein domains.
TL;DR: The dissection of the desmosome by urea into two topographically and biochemically distinct domains should facilitate further studies on the molecular basis of desmosomal adhesion and alpha-keratin filament binding.
14