David Singer

TL;DR: It is shown that binding of methylglyoxal-modified albumin to RAGE results in signal transduction and the high affinity and specificity of hydroimidozolones binding to the V domain of RAGE suggest that they are the primary AGE structures that give rise to AGEs–RAGE pathologies.

TL;DR: The results on the full-length peptides are consistent with a two-step aggregation mechanism originally developed based on studies of the C-terminally truncated analogues, and relatively rapid formation of spherical oligomers containing from 100 to 600 HTT exon1 molecules and intermediate formation of short protofibril-like structures containing from 500 to 2600 molecules.

TL;DR: Fragmentation patterns of synthetic AGE-peptides and assignment of modification-specific signals required for unambiguous structure retrieval are described and conventional bottom-up proteomic approach based on data-dependent acquisition (DDA) LC-MS/MS experiments are incorporated.

TL;DR: Anti-M2e Abs induced by M2e-MAPs are highly cross-reactive and can mediate protection to variant viruses.