David Scalzo
Fred Hutchinson Cancer Research Center
20 Papers
384 Citations
David Scalzo is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Chromatin & Heterochromatin. The author has an hindex of 16, co-authored 20 publications.
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Papers
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote
Dirk Schübeler,David M. MacAlpine,David Scalzo,Christiane Wirbelauer,Charles Kooperberg,Fred van Leeuwen,Daniel E. Gottschling,Laura P. O'Neill,Bryan M. Turner,Jeffrey J. Delrow,Stephen P. Bell,Mark Groudine +11 more
TL;DR: A genome-wide chromatin structure analysis in a higher eukaryote found a binary pattern of histone modifications among euchromatic genes, with active genes being hyperacetylated for H3 and H4 and hypermethylated at Lys 4 and Lys 79 of H3, and inactive genes being hypomethylated and deacetylation at the same residues.
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Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing.
Dirk Schübeler,David Scalzo,Charles Kooperberg,Bas van Steensel,Jeffrey J. Delrow,Mark Groudine,Mark Groudine +6 more
TL;DR: In this article, the authors explored the relationship between DNA replication and gene expression in higher eukaryotes, and developed a strategy to measure the timing of DNA replication for thousands of genes in a single DNA array hybridization experiment.
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•Journal Article
Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing: a link between transcription and replication timing
TL;DR: A strategy to measure the timing of DNA replication for thousands of genes in a single DNA array hybridization experiment generated a genome-wide map of replication timing for Drosophila melanogaster and found a strong correlation between DNA replication early in S phase and transcriptional activity.
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TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends
Ashley M. Wood,Jannie M. Rendtlew Danielsen,Jannie M. Rendtlew Danielsen,Catherine A. Lucas,Ellen L. Rice,David Scalzo,Takeshi Shimi,Robert D. Goldman,Erica D. Smith,Michelle M. Le Beau,Steven T. Kosak +10 more
TL;DR: It is proposed that cellular and organismal ageing are intertwined through the effects of the interaction between TRF2 and lamin A/C on chromosome structure.
Hp1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics
Amy R. Strom,Ronald J Biggs,Edward J. Banigan,Xiaotao Wang,Katherine Chiu,Cameron Herman,Jimena Collado,Feng Yue,Joan C. Ritland Politz,Leah J Tait,David Scalzo,Agnes Telling,Mark Groudine,Clifford P. Brangwynne,John F. Marko,Andrew D. Stephens +15 more
TL;DR: In this paper, the authors used a novel HP1α auxin-inducible degron human cell line to rapidly degrade HP 1α (CBX5) and found that HP 1 α is essential to chromatin-based mechanics and maintains nuclear morphology.
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