David Pollard
Merck & Co.
47 Papers
194 Citations
David Pollard is an academic researcher from Merck & Co.. The author has contributed to research in topics: Chemistry & Ketone. The author has an hindex of 18, co-authored 44 publications. Previous affiliations of David Pollard include Amicus Therapeutics.
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Papers
Biocatalysis for pharmaceutical intermediates: the future is now
David Pollard,John M. Woodley +1 more
TL;DR: This review describes how demands are being addressed to make biocatalysis successful, particularly by the use of micro-scale technology for high-speed catalyst screening and process development alongside discipline integration of biology and engineering with chemistry.
731
Advances in the Enzymatic Reduction of Ketones
TL;DR: An understanding of the capabilities and limitations of the isolated ketoreductases is presented, making biocatalysis the general method of choice for ketone reductions.
313
Enzyme-Catalyzed Enantioselective Diaryl Ketone Reductions
TL;DR: The synthesis of diarylmethanols via the reduction of a range of substituted benzophenone and benzoylpyridine derivatives with ketoreductase enzymes with KREDs has afforded chiral products with high yield and ee with good selectivity.
125
Enzymatic ketone reductions with co-factor recycling: Improved reactions with ionic liquid co-solvents
TL;DR: For two pharmaceutically relevant ketone reductions mediated by isolated enzymes the stability of both the ADH RE and the GDH 103 co-enzyme was found to be enhanced by the presence of certain ionic liquids compared to both organic solvents and aqueous buffer.
82
Automated disposable small scale reactor for high throughput bioprocess development: a proof of concept study.
TL;DR: Proof of concept evaluations of an automated disposable small scale reactor for high throughput upstream process development are described, showing the technology was shown to be robust across multiple runs and met the requirements for the ability to run high cell density processes with exponential feeds and sophisticated event triggered processes.
81