David Partida

TL;DR: A new mouse model is reported in which expression of the endogenous Aurkb locus can be induced in vitro and in vivo, and overexpression of Aurora B may contribute to tumor formation not only by inducing chromosomal instability but also by suppressing the function of the cell cycle inhibitor p21Cip1.

TL;DR: Characterization of 5 highly conserved non-coding sequences from the PPARγ locus may enable isolation of the transcription factors that bind these cis elements and provide insight into the molecular regulation of adipose tissue expansion in normal and pathological states.

TL;DR: It is shown here that Polo-like kinase 1 (Plk1) is required for endomitosis, and ablation of the Plk1 gene in megakaryocytes results in defective polyploidization accompanied by mitotic arrest and cell death, raising a note of caution in the use of PlK1 inhibitors in therapeutic strategies based on polyploidsization regulators.

TL;DR: It is shown that MASTL overexpression predicts poor survival and shows prognostic value in breast cancer patients and that genetic ablation of MastL displays a significant therapeutic effect in vivo, suggesting that the PP2A inhibitory kinase MASTl may have both prognostic and therapeutic value in human breast cancer.