David P. Dickson
University of Illinois at Chicago
10 Papers
152 Citations
David P. Dickson is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Negishi coupling & Homogeneous catalysis. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of David P. Dickson include Bayer & University of California, Santa Barbara.
Chat about Author
Papers
Inspiring process innovation via an improved green manufacturing metric: iGAL
Frank Roschangar,Yanyan Zhou,David J. C. Constable,Juan Colberg,David P. Dickson,Peter J. Dunn,Martin D. Eastgate,Fabrice Gallou,John D. Hayler,Stefan G. Koenig,Michael E. Kopach,David K. Leahy,Ingrid Mergelsberg,Ulrich Scholz,Austin G. Smith,Manuel Henry,Jason A. Mulder,Jörg Brandenburg,Juan M. Rodriguez Dehli,Daniel R. Fandrick,Keith R. Fandrick,Frieder Gnad-Badouin,Georg Zerban,Klaus Groll,Paul T. Anastas,Roger A. Sheldon,Roger A. Sheldon,Chris H. Senanayake +27 more
TL;DR: iGAL accurately captures the impact of green process inventiveness and improvements, making it a useful innovation-driven green metric, and introduces the comprehensive, yet easy-to-use and readily adaptable Green Chemistry Innovation Scorecard web calculator.
79
Total synthesis of (+/-)-agelastatin A, a potent inhibitor of osteopontin-mediated neoplastic transformations.
TL;DR: A stereoselective synthesis of agelastatin A, a potent cytotoxin and inhibitor of osteopontin (OPN)-mediated neoplastic transformations, has been accomplished in 14 steps (12 operations) with an approximate overall yield of 8%.
56
Improved iGAL 2.0 Metric Empowers Pharmaceutical Scientists to Make Meaningful Contributions to United Nations Sustainable Development Goal 12
Frank Roschangar,Jun Li,Yanyan Zhou,Wim Aelterman,Alina Borovika,Juan Colberg,David P. Dickson,Fabrice Gallou,Roger A. Sheldon,Roger A. Sheldon +9 more
TL;DR: It is demonstrated that iGAL 2.0 is based upon an improved statistical model that enables determination of meaningful API waste figures and early identification of potentially underperforming and environmentally more concerning processes, thereby delivering both environmental and economic value.
A New Bromo Trienyne: Synthesis of all-E, Conjugated Tetra-, Penta-, and Hexaenes Common to Oxo Polyene Macrolide Antibiotics.
Bruce H. Lipshutz,Brett R. Ullman,Craig W. Lindsley,Sabina Pecchi,Daniel J. Buzard,David P. Dickson +5 more
TL;DR: The overall stereochemical outcome of these reactions, as noted previously, is such that essentially all-E products are obtained notwithstanding the g85:15 mix of polyenynes 7 formed from the vinyl-vinyl cross-coupling/desilylation.
32
Total Synthesis of (.+-.)-Agelastatin A (I), a Potent Inhibitor of Osteopontin-Mediated Neoplastic Transformations.
Abstract: A stereoselective synthesis of agelastatin A, a potent cytotoxin and inhibitor of osteopontin (OPN)-mediated neoplastic transformations, has been accomplished in 14 steps (12 operations) with an approximate overall yield of 8%. Notable features of this route include the direct manner in which the pyrroloketopiperazine A-ring of the target is generated and the efficient employment of a trichloroacetamide, introduced through Overman rearrangement, as a protecting group, pendant nucleophile, and latent urea.
30