David Monteith
Eli Lilly and Company
13 Papers
63 Citations
David Monteith is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Tolerability & Pharmacokinetics. The author has an hindex of 9, co-authored 13 publications.
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Papers
•Journal Article
In Vivo Distribution and Metabolism of a Phosphorothioate Oligonucleotide within Rat Liver after Intravenous Administration
Mark J. Graham,Stanley T. Crooke,David Monteith,Scott Cooper,Kristina M. Lemonidis,Kim K. Stecker,Michael J. Martin,Rosanne M. Crooke +7 more
TL;DR: The results suggest that although pharmacokinetic parameters vary as a function of hepatic cell type, significant intracellular delivery can be readily achieved in the liver after systemic administration.
141
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the CGRP Binding Monoclonal Antibody LY2951742 (Galcanezumab) in Healthy Volunteers
David Monteith,Emily C. Collins,Corinne Vandermeulen,Anne Van Hecken,Eyas Raddad,Joel C Scherer,David Grayzel,Thomas J Schuetz,Jan de Hoon +8 more
TL;DR: Galcanezumab induced a robust, dose-dependent, and durable inhibition of capsaicin-induced increase in dermal blood flow in DBF, supporting the continued clinical development of galcaneZumab for prophylaxis in migraine patients.
In vitro assays and biomarkers for drug-induced phospholipidosis
TL;DR: Any screening approach, while assessing the potential to induce phospholipidosis, must be considered in relation to prediction of findings in vivo, and the status of current assays and biomarkers is presented with strategies for screening.
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A clinical flow cytometric biomarker strategy: validation of peripheral leukocyte phospholipidosis using Nile red
Bartley W. Halstead,Craig Zwickl,Ryan E. Morgan,David Monteith,Craig E. Thomas,Rita K. Bowers,Brian R. Berridge +6 more
TL;DR: Flow cytometry, coupled with the lipophilic fluoroprobe Nile red, was correlated to histopathology, electron microscopy and inorganic phosphorus detection to validate the utility of this method for monitoring phospholipidosis in peripheral blood leukocytes, and it was demonstrated that flow cytometric analysis of Nile red stained lysed whole blood can be used to detect drug‐induced phospholIPid accumulation in circulating peripheralLeukocytes.
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