David Moncol
Research Triangle Park
7 Papers
169 Citations
David Moncol is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Agonist & GPR120. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of David Moncol include GlaxoSmithKline.
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Papers
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)
Steven M. Sparks,Grace Chen,Jon L. Collins,Dana P. Danger,Dock Steven Thomas,Channa K Jayawickreme,Stephen Jenkinson,Christopher P. Laudeman,M. Anthony Leesnitzer,Xi Liang,Patrick R. Maloney,David C McCoy,David Moncol,Vincent Rash,Thomas J. Rimele,Padmaja Vulimiri,James M. Way,Sean Ross +17 more
TL;DR: The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described, which led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective F FA4 antagonist 39.
104
Synthesis and structure-activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists.
Brian Budzik,Karen A. Evans,David D. Wisnoski,Jian Jin,Ralph A. Rivero,George R. Szewczyk,Channa Jayawickreme,David Moncol,Hongshi Yu +8 more
TL;DR: A series of 3-aryl-4-isoxazolecarboxamides identified from a high-throughput screening campaign as novel, potent agonists of the human TGR5 G-protein-coupled receptor is described.
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Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist.
Steven M. Sparks,Christopher Joseph Aquino,Pierette Banker,Jon L. Collins,David J. Cowan,Caroline J. Diaz,Dock Steven Thomas,Donald L. Hertzog,Xi Liang,Erin Swiger,Josephine Yuen,Grace Chen,Channa K Jayawickreme,David Moncol,Christopher Nystrom,Vincent Rash,Thomas J. Rimele,Shane Roller,Sean Ross +18 more
TL;DR: Work to identify agonists with appropriate pharmacokinetic properties to support progression into in vivo studies led to the identification of compound 29, a FFA4 agonist which lowers plasma glucose in two preclinical models of type 2 diabetes.
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Synthesis and Structure—Activity Relationships of a Series of 3-Aryl-4-isoxazolecarboxamides as a New Class of TGR5 Agonists.
Brian Budzik,Karen A. Evans,David D. Wisnoski,Jian Jin,Ralph A. Rivero,George R. Szewczyk,Channa Jayawickreme,David Moncol,Hongshi Yu +8 more
TL;DR: A series of 3-aryl-4-isoxazolecarboxamides identified from a high-throughput screening campaign as novel, potent agonists of the human TGR5 G-protein-coupled receptor is described in this paper.
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Functional screening in the melanophore bioassay.
Channa K Jayawickreme,Howard Ray Sauls,Chris Watson,David Moncol,Thomas J. Rimele,Terry P. Kenakin +5 more
TL;DR: The melanophore bioassay is a robust, sensitive, and versatile procedure for screening G protein–coupled receptors in a variety of formats and can yield conventional agonist‐antagonist as well as constitutive assays.
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