David McLeod
Ontario Institute for Cancer Research
33 Papers
158 Citations
David McLeod is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: Wittig reaction & Enantioselective synthesis. The author has an hindex of 12, co-authored 33 publications. Previous affiliations of David McLeod include McMaster University & Aarhus University.
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Papers
Expanding the Frontiers of Higher-Order Cycloadditions.
David McLeod,Mathias Kirk Thøgersen,Nicolaj Inunnguaq Jessen,Karl Anker Jørgensen,Cooper S. Jamieson,Xiao-Song Xue,K. N. Houk,Fang Liu,Roald Hoffmann +8 more
TL;DR: The history and recent progress in higher-order cycloadditions are described, and how these advances have been made by collaborative experimental and computational studies are described.
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Microwave-Assisted, Aqueous Wittig Reactions: Organic-Solvent- and Protecting-Group-Free Chemoselective Synthesis of Functionalized Alkenes.
TL;DR: A variety of triethylallyl and triethylbenzyl phosphonium bromides are prepared with nearly quantitative yields by the direct reaction of triethyphosphane hydrobromide and alcohols under conventional heating and neat conditions.
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A direct synthesis of functionalized styrenes and terminal 1,3-dienes via aqueous Wittig chemistry with formalin
TL;DR: In this article, a direct synthesis of functionalized styrenes including synthetically valuable styryl halides and terminal 1,3-dienes was reported directly from benzylic and allylic alcohols and aqueous formalin involving microwave assisted phosphonium salt formation and Wittig olefination under mildly basic conditions.
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Higher-order cycloadditions in the age of catalysis
TL;DR: In this paper, the authors classified organocatalytic HOCs based on the generated cycloaddends and analyzed the factors that played a crucial role to the feasibility of their formation and usage.
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Development of a robust reagent for the two-carbon homologation of aldehydes to (E)-α,β-unsaturated aldehydes in water
TL;DR: In this article, the synthesis of a pinacolacetal-phosphonium salt and its reaction with aldehydes to give homologated acetals and two-carbon homologation of unsaturated aldehyde is presented.
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