David Macías
4 Papers
David Macías is an academic researcher. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 1, co-authored 4 publications.
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Papers
Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.
Scott Haston,Estela Gonzalez-Gualda,Samir Morsli,Jianfeng Ge,V. Reen,I. Moutsopoulos,Leonidas Panousopoulos,Polina Deletic,Gabriela Carreno,Romain Guiho,Saba Manshaei,Jose Mario Gonzalez-Meljem,Daniel J. Simpson,Jodie Birch,Husayn A. Pallikonda,Tamir Chandra,David Macías,Gary J. Doherty,Doris Rassl,Robert C. Rintoul,Massimo Signore,Irina Mohorianu,Arne N. Akbar,Jesús Gil,Daniel Muñoz-Espín,Juan Pedro Martinez-Barbera +25 more
TL;DR: In this article , the authors identify a population of tumor-associated macrophages that express a unique array of pro-tumorigenic SASP factors and surface proteins and are also present in normal aged lungs.
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A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer
Estela Gonzalez-Gualda,David Macías,Samir Morsli,Jose Ezequiel Martin,Hui-Ling Ou,M. Denholm,Ioana Olan,Reuben J. Hoffmann,Mark A. Dane,Dimitris Veroutis,Guillermo Medrano,Francisca Mulero,Carla P. Martins,Mariano Barbacid,Vassilis G. Gorgoulis,James E. Korkola,Doris Rassl,Gary J. Doherty,Robert C. Rintoul,Masashi Narita,Daniel Muñoz-Espín +20 more
TL;DR: It is shown that cisplatin-derived SASP enhances the malignant phenotype of lung cancer cells, and addition of TGFBR1 inhibitors to platinum-based chemotherapy reduces tumour burden and improves survival, providing pre-clinical proof-of-concept for future trial designs.
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In Vivo Monitoring of Cellular Senescence by Photoacoustic and Fluorescence Imaging Utilizing a Nanostructured Organic Probe
Andrew G. Baker,Hui-Ling Ou,A. Bistrović Popov,Emma L. Brown,James Joseph,Monika A. Golinska,Chandan Sanghera,Estela Gonzalez-Gualda,David Macías,Thomas R. Else,Heather F. Greer,Aude Vernet,Sarah E. Bohndiek,Ljiljana Fruk,Daniel Muñoz-Espín +14 more
TL;DR: In this article , a nanostructured organic probe (NanoJaggs) based on biocompatible indocyanine green dye (ICG) building blocks forming Jaggregates, which possess distinct spectral properties allowing both fluorescence and photoacoustic tomography (PAT) detection.
Abstract 5504: A tumor-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer
Estela Gonzalez-Gualda,David Macías,Samir Morsli,Jose Ezequiel Martin,Hui-Ling Ou,M. Denholm,Ioana Olan,Reuben J. Hoffmann,Mark A. Dane,Dimitris Veroutis,Guillermo Medrano,Francisca Mulero,Carla P. Martins,Mariano Barbacid,Vassilis G. Gorgoulis,James E. Korkola,Doris Rassl,Gary J. Doherty,Robert C. Rintoul,Masashi Narita,Daniel Muñoz-Espín +20 more
TL;DR: Gualda et al. as mentioned in this paper showed that adding TGFBR1 inhibitors to platinum-based chemotherapy reduces tumor burden and improves survival, providing pre-clinical proof-of-concept for future trial designs on combination therapies.