David M. Jacobowitz
Uniformed Services University of the Health Sciences
18 Papers
98 Citations
David M. Jacobowitz is an academic researcher from Uniformed Services University of the Health Sciences. The author has contributed to research in topics: Traumatic brain injury & Neuroprotection. The author has an hindex of 13, co-authored 18 publications.
Chat about Author
Papers
PET imaging of brain with the β-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer’s disease
Hiroshi Toyama,Hiroshi Toyama,Daniel Ye,Masanori Ichise,Jeih San Liow,Lisheng Cai,David M. Jacobowitz,John L. Musachio,Jinsoo Hong,Mathew Crescenzo,Dnyanesh Tipre,Jian Qiang Lu,Sami S. Zoghbi,Douglass Vines,Jurgen Seidel,Kazuhiro Katada,Michael V. Green,Victor W. Pike,Robert M. Cohen,Robert B. Innis +19 more
TL;DR: Marked reductions in brain uptake of this radioligand in transgenic mice may be due to reduced cerebral blood flow relative to that in wild-type mice, and specific [11C]6-OH-BTA-1 binding to Aβ plaques, if any, is probably very low, as reflected in the small FR/CE and PA/CE ratio differences.
136
Capsaicin and potassium evoked substance P release from the nucleus tractus solitarius and spinal trigeminal nucleus in vitro
TL;DR: The capsaicin data support the contention that this agent elicits release of substance P from nuclear regions receiving peripheral afferent information in substance P nerves independent of the particular sensory modality served but is ineffective in nonsensory areas.
67
Extensive aspartoacylase expression in the rat central nervous system.
John R. Moffett,Peethambaran Arun,Prasanth S. Ariyannur,James Y. Garbern,David M. Jacobowitz,Aryan M.A. Namboodiri +5 more
TL;DR: Aspartoacylase (ASPA) catalyzes deacetylation of N-acetylaspartate (NAA) to generate acetate and aspartate as discussed by the authors.
58
Alpha-linolenic acid is a potent neuroprotective agent against soman-induced neuropathology ☆
Hongna Pan,Xian-Zhang Hu,David M. Jacobowitz,Cynthia Chen,John H. McDonough,Kerry E. Van Shura,Megan E Lyman,Ann M. Marini +7 more
TL;DR: It is shown that α-linolenic acid is neuroprotective against soman-induced neuropathology in either a pretreatment or post-treatment paradigm and that subcutaneous injection of α-Linolenic Acid shows greater neuroprot protective efficacy compared with intravenous injection in a brain region-specific manner.
46
"Soldier's Heart": A Genetic Basis for Elevated Cardiovascular Disease Risk Associated with Post-traumatic Stress Disorder.
Harvey B. Pollard,Chittari Shivakumar,Joshua Starr,Ofer Eidelman,David M. Jacobowitz,Clifton L. Dalgard,Meera Srivastava,Matthew D. Wilkerson,Murray B. Stein,Robert J. Ursano +9 more
TL;DR: The findings offer quantitative evidence for a genetic link between post-traumatic stress and cardiovascular disease, Computationally, the common mechanism for this linkage between PTSD and CVD is innate immunity and NFκB-mediated inflammation.