David Laperrière
Université de Montréal
21 Papers
30 Citations
David Laperrière is an academic researcher from Université de Montréal. The author has contributed to research in topics: Regulation of gene expression & Breast cancer. The author has an hindex of 12, co-authored 21 publications. Previous affiliations of David Laperrière include McGill University.
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Papers
Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes.
Tian-Tian Wang,Luz E. Tavera-Mendoza,David Laperrière,Eric Libby,Naomi Burton MacLeod,Yoshihiko Nagai,Véronique Bourdeau,Anna Konstorum,Benjamin Lallemant,Rui Zhang,Sylvie Mader,John H. White +11 more
TL;DR: The combined approaches used here provide numerous insights into the direct target genes underlying the broad physiological actions of 1,25(OH)2D3.
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Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease
Tian-Tian Wang,Basel Dabbas,David Laperrière,Ari J. Bitton,Hafid Soualhine,Luz E. Tavera-Mendoza,Serge Dionne,Marc J. Servant,Alain Bitton,Ernest G. Seidman,Sylvie Mader,Marcel A. Behr,John H. White +12 more
TL;DR: Hormonal vitamin D, 1,25-dihydroxyvitamin D3, robustly stimulates expression of pattern recognition receptor NOD2/CARD15/IBD1 gene and protein in primary human monocytic and epithelial cells, providing strong molecular links between vitamin D deficiency and the genetics of Crohn disease, a chronic incurable inflammatory bowel condition.
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The Transcription Factor Encyclopedia
Dimas Yusuf,Stefanie L. Butland,Magdalena I. Swanson,Eugene Bolotin,Amy Ticoll,Warren A. Cheung,Xiao Yu Cindy Zhang,Christopher Td Dickman,Debra L. Fulton,Jonathan Lim,Jake Schnabl,Oscar H. P. Ramos,Mireille Vasseur-Cognet,Charles N. de Leeuw,Elizabeth M. Simpson,Gerhart U. Ryffel,Eric Lam,Ralf Kist,Miranda Sc Wilson,Raquel Marco-Ferreres,Jan J. Brosens,Leonardo Beccari,Paola Bovolenta,Bérénice A. Benayoun,Lara J. Monteiro,Helma Dc Schwenen,Lars Grøntved,Elizabeth D. Wederell,Susanne Mandrup,Reiner A. Veitia,Harini Chakravarthy,Pamela A. Hoodless,M. Michela Mancarelli,Bruce E. Torbett,Alison H. Banham,Sekhar P. Reddy,Rebecca L. Cullum,Michaela Liedtke,Mario P. Tschan,Michelle Vaz,Angie Rizzino,Mariastella Zannini,Seth Frietze,Peggy J. Farnham,Astrid Eijkelenboom,Philip J. Brown,David Laperrière,Dominique Leprince,Tiziana de Cristofaro,Kelly L. Prince,Marrit Putker,Luis del Peso,Gieri Camenisch,Roland H. Wenger,Michal Mikula,Marieke Rozendaal,Sylvie Mader,Jerzy Ostrowski,Simon J. Rhodes,Capucine Van Rechem,Gaylor Boulay,Sam W. Z. Olechnowicz,Mary B. Breslin,Michael S. Lan,Kyster K. Nanan,Michael Wegner,Juan Hou,Rachel D. Mullen,Stephanie C. Colvin,Peter J. Noy,Carol F. Webb,Matthew E. Witek,Scott Ferrell,Juliet M. Daniel,Jason Y. Park,Scott A. Waldman,Daniel J. Peet,Michael J. Taggart,Padma-Sheela Jayaraman,Julien J. Karrich,Bianca Blom,Farhad Vesuna,Henriette O'Geen,Yunfu Sun,Richard M. Gronostajski,Mark W. Woodcroft,Margaret R. Hough,Edwin Chen,Nicholas Europe-Finner,Magdalena Karolczak-Bayatti,Jarrod Bailey,Oliver Hankinson,Venu Raman,David P. LeBrun,Shyam Biswal,Christopher J. Harvey,Jason P. DeBruyne,John B. Hogenesch,Robert F. Hevner,Christophe Héligon,Xin M. Luo,Marissa Cathleen Blank,Kathleen J. Millen,David S. Sharlin,Douglas Forrest,Karin Dahlman-Wright,Chunyan Zhao,Yuriko Mishima,Satrajit Sinha,Rumela Chakrabarti,Elodie Portales-Casamar,Frances M. Sladek,Philip Bradley,Wyeth W. Wasserman +113 more
TL;DR: The Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration, is presented.
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Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution
TL;DR: Mapping the positions of all consensus DR-type hormone response elements in the human genome found that DR2 motifs, recognized by retinoic acid receptors (RARs), are heavily overrepresented, providing strong support for the notion that Alu-mediated expansion of DR elements contributed to the evolution of gene regulation by RARs and other nuclear receptors in primates and humans.
Evolution of the repertoire of nuclear receptor binding sites in genomes.
TL;DR: The presence of NR binding sites in the primate-specific Alu family of short-interspersed elements has been shown to confer transcriptional regulation by NRs to adjacent genes, although the impact on NR regulatory networks at the genome-wide scale remains to be more fully evaluated.
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