David L. Ebenezer
University of Illinois at Chicago
20 Papers
27 Citations
David L. Ebenezer is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Lung injury & Sphingosine-1-phosphate. The author has an hindex of 10, co-authored 19 publications.
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Papers
Reactive oxygen species at the crossroads of inflammasome and inflammation.
TL;DR: Dysregulation of inflammasome plays a significant role in various pathological processes and could serve as future therapeutic targets for various pathological conditions.
Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts
Long Shuang Huang,Tara Sudhadevi,Panfeng Fu,Prasanth-Kumar Punathil-Kannan,David L. Ebenezer,Ramaswamy Ramchandran,Vijay Putherickal,Paul Cheresh,Paul Cheresh,Guofei Zhou,Alison W. Ha,Anantha Harijith,David W. Kamp,David W. Kamp,Viswanathan Natarajan +14 more
TL;DR: A role for SPHK1/S1P signaling in TGF-β-induced YAP1 activation and mtROS generation is suggested, resulting in fibroblast activation, a critical driver of pulmonary fibrosis.
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Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy
Long Shuang Huang,Evgeny V. Berdyshev,John T. Tran,Lishi Xie,Jiwang Chen,David L. Ebenezer,Biji Mathew,Irina Gorshkova,Wei Zhang,Sekhar P. Reddy,Anantha Harijith,Gang Wang,Carol Feghali-Bostwick,Imre Noth,Shwu Fan Ma,Tong Zhou,Wenli Ma,Joe G.N. Garcia,Viswanathan Natarajan +18 more
TL;DR: It is suggested that S1PL is a novel endogenous suppressor of pulmonary fibrosis in human IPF and animal models.
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Targeting sphingosine-1-phosphate signaling in lung diseases.
TL;DR: The SphKs /S1P / S1PL metabolic pathway is implicated in numerous human pathologies including respiratory disorders, thereby raising the possibility that manipulating intracellular S1P levels could offer therapeutic potential in ameliorating lung diseases.
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Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.
David L. Ebenezer,Evgeny Berdyshev,Irina Bronova,Yuru Liu,Chinnaswamy Tiruppathi,Yulia Komarova,Elizaveta V. Benevolenskaya,Vidyani Suryadevara,Alison W. Ha,Anantha Harijith,Rubin M. Tuder,Viswanathan Natarajan,Panfeng Fu +12 more
TL;DR: A critical role for nuclear SPHK2/S1P signalling in epigenetic regulation of bacterial-mediated inflammatory lung injury is defined and may represent a potential strategy to reduce lung inflammatory pulmonary disorders such as pneumonia and CF.
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