David L. Corcoran
Duke University
136 Papers
454 Citations
David L. Corcoran is an academic researcher from Duke University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 33, co-authored 105 publications. Previous affiliations of David L. Corcoran include University of Pittsburgh & King's College London.
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Papers
Quantification of biological aging in young adults.
Daniel W. Belsky,Avshalom Caspi,Renate Houts,Harvey J. Cohen,David L. Corcoran,Andrea Danese,HonaLee Harrington,Salomon Israel,Morgan E. Levine,Jonathan D. Schaefer,Karen Sugden,Ben Williams,Anatoli I. Yashin,Richie Poulton,Terrie E. Moffitt +14 more
TL;DR: It is indicated that aging processes can be quantified in people still young enough for prevention of age-related disease, opening a new door for antiaging therapies.
906
FMRP targets distinct mRNA sequence elements to regulate protein expression
Manuel Ascano,Neelanjan Mukherjee,Pradeep Bandaru,Jason B. Miller,Jeffrey Nusbaum,David L. Corcoran,Christine Langlois,Mathias Munschauer,Scott Dewell,Markus Hafner,Zev Williams,Zev Williams,Uwe Ohler,Thomas Tuschl +13 more
TL;DR: The discovery of distinct RNA-recognition elements that correspond to the two independent RNA-binding domains of FMRP and the discovery that these targets are also dysregulated in Fmr1−/− mouse ovaries showing signs of premature follicular overdevelopment indicate that FMRp targets share signalling pathways across different cellular contexts.
719
Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability
Neelanjan Mukherjee,David L. Corcoran,Jeffrey Nusbaum,Jeffrey Nusbaum,David W. Reid,Stoyan Georgiev,Markus Hafner,Markus Hafner,Manuel Ascano,Manuel Ascano,Thomas Tuschl,Thomas Tuschl,Uwe Ohler,Jack D. Keene +13 more
TL;DR: Comparison of the spatial patterns surrounding HuR and miRNA binding sites provided functional evidence for HuR-dependent antagonism of proximal miRNA-mediated repression and it is concluded that HuR coordinates gene expression outcomes at multiple interconnected steps of RNA processing.
690
Is Adult ADHD a Childhood-Onset Neurodevelopmental Disorder? Evidence From a Four-Decade Longitudinal Cohort Study
Terrie E. Moffitt,Renate Houts,Philip Asherson,Daniel W. Belsky,David L. Corcoran,Maggie Hammerle,HonaLee Harrington,Sean Hogan,Madeline H. Meier,Guilherme V. Polanczyk,Richie Poulton,Sandhya Ramrakha,Karen Sugden,Benjamin Williams,Luis Augusto Rohde,Avshalom Caspi +15 more
TL;DR: The findings raise the possibility that adults presenting with the ADHD symptom picture may not have a childhood-onset neurodevelopmental disorder, and the disorder's place in the classification system must be reconsidered.
569
Inhibition and role of let-7d in idiopathic pulmonary fibrosis.
Kusum Pandit,David L. Corcoran,Hanadie Yousef,Manohar Yarlagadda,Argyris Tzouvelekis,Kevin F. Gibson,Kazuhisa Konishi,Samuel A. Yousem,Mandal K. Singh,Daniel Handley,Thomas J. Richards,Moisés Selman,Simon C. Watkins,Annie Pardo,Ahmi Ben-Yehudah,Demosthenes Bouros,Oliver Eickelberg,Prabir Ray,Panayiotis V. Benos,Naftali Kaminski +19 more
TL;DR: The down-regulation of let-7d in IPF and the profibrotic effects of this down- regulation in vitro and in vivo suggest a key regulatory role for this microRNA in preventing lung fibrosis.