David Kolar
Charles University in Prague
8 Papers
23 Citations
David Kolar is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Mitochondrion & Medicine. The author has an hindex of 3, co-authored 5 publications.
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Papers
Desmin Knock-Out Cardiomyopathy: A Heart on the Verge of Metabolic Crisis
Barbara Elsnicova,Daniela Hornikova,Veronika Tibenska,David Kolar,Tereza Tlapakova,Benjamin Schmid,Markus Mallek,Britta Eggers,Ursula Schlötzer-Schrehardt,Viktoriya Peeva,Carolin Berwanger,Bettina Eberhard,Hacer Durmus,Dorothea Schultheis,C. S. Holtzhausen,Karin Schork,Katrin Marcus,Jens Jordan,Thomas Lücke,Peter F. van der Ven,H. Schröder,Christoph S. Clemen,Jitka Zurmanova +22 more
TL;DR: Desmin deficiency elicits a secondary cardiac mitochondriopathy with severely impaired oxidative phosphorylation and fatty and amino acid metabolism, and it may be prudent to avoid medications worsening mitochondrial function and other metabolic stressors.
Adaptation to chronic continuous hypoxia potentiates Akt/HK2 anti-apoptotic pathway during brief myocardial ischemia/reperfusion insult.
David Kolar,Milada Gresikova,Petra Waskova-Arnostova,Barbara Elsnicova,Jana Kohutova,Daniela Hornikova,Pavel Vebr,Jan Neckar,Tereza Blahova,Dita Kasparova,Jiri Novotny,Frantisek Kolar,Olga Novakova,Jitka Zurmanova +13 more
TL;DR: The Akt/HK2 pathway is likely to play a role in the development of a cardioprotective phenotype of CNH by preventing the detachment of HK2 from mitochondria at reperfusion period and decreases the Bax/Bcl-2 ratio during I/R insult, thereby lowering the probability of apoptosis activation in the mitochondrial compartment.
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Gradual cold acclimation induces cardioprotection without affecting β-adrenergic receptor-mediated adenylyl cyclase signaling.
Veronika Tibenska,Aneta Benesova,Pavel Vebr,Andrea Liptáková,Lucie Hejnova,Barbara Elsnicova,Zdenek Drahota,Daniela Hornikova,Frantisek Galatík,David Kolar,Stanislav Vybíral,Petra Alánová,Jiri Novotný,Frantisek Kolar,Olga Novakova,Olga Novakova,Jitka Zurmanova +16 more
TL;DR: In this paper, a new model of mild gradual cold acclimation increasing tolerance to myocardial ischemia/reperfusion injury without hypertension and hypertrophy was presented.
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Mitochondrial genome modulates myocardial Akt/Glut/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia.
Iveta Nedvedova,David Kolar,Barbara Elsnicova,Daniela Hornikova,Jiri Novotny,Martin Kalous,Michal Pravenec,Jan Neckar,Frantisek Kolar,Jitka Zurmanova +9 more
TL;DR: Examining the possible involvement of the hypoxia inducible factor (HIF)-dependent pathway of the protein kinase B/glucose transporters/hexokinase (Akt/GLUT/HK) in this mitochondrial genome-related difference of the cardioprotective phenotype concluded that Pleiotropic effects of upregulated Akt2 along with HK translocation to mitochondria and mitochondria-associated membranes can potentially contribute to a stronger CNH-afford
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Glycolytic and Krebs cycle enzymes activity in rat prefrontal cortex, hippocampus, and striatum after single and repeated NMDA inhibition by MK-801.
TL;DR: In this article , the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 was used to experimentally induce psychosis-like behavior in rats, and the results indicated a progressive metabolic dysregulation of glycolytic and Krebs cycle enzymes following repeated inhibition of NMDA receptors activity.
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