David Jimenez-Morales

TL;DR: Single-cell profiling demonstrates multifarious dysregulation of innate immune phenotype associated with COVID-19 severity, which is associated with hyperactivation of neutrophils and NK cells, while monocytes take on tolerogenic phenotypes.

TL;DR: A genome-wide CRISPR-Cas9 screen and secondary targeted screens in U937 human monocyte/macrophage-like cells are performed to systematically identify host factors that regulate killing by L.pneumophila and provide a wealth of previously undescribed insights into L. p pneumophila pathogenesis and mammalian cell function.

TL;DR: Apolipoprotein (apo) E4-induced bioenergetic deficits led to extensive metabolic rewiring, but despite numerous cellular adaptations, apoE4-expressing neurons remained vulnerable to metabolic stress and insights into potential molecular targets of therapies to correct ApoE 4-associated mitochondrial dysfunction and altered cellular metabolism are provided.

TL;DR: It is proposed that ZIKV, via the capsid protein, has evolved a strategy to lower UPF1 levels and dampen antiviral activities of NMD, which in turn contributes to neuropathology in vivo.