David J. Young
National Institutes of Health
28 Papers
28 Citations
David J. Young is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Translation (biology). The author has an hindex of 6, co-authored 13 publications.
Chat about Author
Papers
Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag.
Thomas Winkler,Xing Fan,James K. Cooper,Ronan Desmond,David J. Young,Danielle M. Townsley,Phillip Scheinberg,Sophia Grasmeder,Andre Larochelle,Marie J. Desierto,Janet Valdez,Jennifer Lotter,Colin Wu,Ruba Shalhoub,Katherine R. Calvo,Neal S. Young,Cynthia E. Dunbar +16 more
TL;DR: Extended administration of EPAG at a dose of 150 mg for 24 weeks rescued responses in some patients with rSAA not responding at 12 weeks, suggesting that EPAG may promote expansion of dormant preexisting clones with an aberrant karyotype.
92
Tma64/eIF2D, Tma20/MCT-1, and Tma22/DENR Recycle Post-termination 40S Subunits In Vivo.
David J. Young,Desislava S. Makeeva,Fan Zhang,Aleksandra S. Anisimova,Elena Stolboushkina,Fardin Ghobakhlou,Ivan N. Shatsky,Sergey E. Dmitriev,Sergey E. Dmitriev,Alan G. Hinnebusch,Nicholas R. Guydosh +10 more
TL;DR: It is found that unrecycled ribosomes could reinitiate translation at AUG codons in the 3' UTR, as evidenced by peaks in the footprint data and 3'UTR reporter analysis and that reinitiation increased in the absence of Tma64, Tma20, and Tma22.
76
Eltrombopag for patients with moderate aplastic anemia or uni-lineage cytopenias
Xing Fan,Ronan Desmond,Thomas Winkler,David J. Young,Bogdan Dumitriu,Danielle M. Townsley,Fernanda Gutierrez-Rodrigues,Jennifer Lotter,Janet Valdez,Stephanie Sellers,Ma Evette Barranta,Ruba Shalhoub,Colin O. Wu,Maher Albitar,Katherine R. Calvo,Neal S. Young,Cynthia E. Dunbar +16 more
TL;DR: Eltrombopag (EPAG) is a well-tolerated oral treatment of cytopenias in patients with MAA/UC and was discontinued for robust or stable blood counts in 12 of 17 patients after a median of 8 months.
40
Hcr1/eIF3j Is a 60S Ribosomal Subunit Recycling Accessory Factor In Vivo.
TL;DR: Findings suggest Hcr1/eIF3j is recruited to ribosomes at stop codons and may coordinate the transition to a new round of translation in 3' UTRs, consistent with a 60S recycling role.
39
Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs
Swati Gaikwad,Fardin Ghobakhlou,David J. Young,Jyothsna Visweswaraiah,Hongen Zhang,Alan G. Hinnebusch +5 more
TL;DR: This article showed that strong mRNAs outcompete weak mRNA in response to 43S pre-initiation complex limitation achieved in various ways, in accordance with previous mathematical modeling.
30