David J. Carlile

TL;DR: An appreciation of the utility of in vitro prediction can be best achieved when therange of CLint values predicted from the individual hepatic microsomal samples are compared with the range of individual in vivo Clint values reported in the literature.

TL;DR: This research attacked the mode of action of EMTs by targeting the “spatially aggregating” response of the immune system through a number of mechanisms, including “cell reprograming” and “drug-like” responses.

TL;DR: The kinetics of ethoxycoumarin O-deethylation have been determined under varying conditions of hepatic cytochrome P-450 activity and the degree of underestimation was dependent on the magnitude of intrinsic clearance and was consistent with the theory that within precision-cut liver slices intercellular transport occurs in parallel with cellular metabolism.

TL;DR: In this article , the authors report on the durability of response with glofitamab SUD in a larger cohort with additional follow up, showing that patients with a CR remained in response at 9 months.