David J. Bzik

TL;DR: The findings reveal that enolase functions extend beyond glycolytic activity and include a direct role in coordinating gene regulation in T. gondii, and is targeted to the nucleus of actively replicating parasites, where it specifically binds to nuclear chromatin in vivo.

TL;DR: It is speculated that a better understanding of host-parasite interaction at the molecular level and applying improved genetic models based on Δku80 Toxoplasma strains will stimulate development of highly effective immunotherapeutic cancer vaccine strategies using engineered uracil auxotrophs.

TL;DR: It is shown that soluble parasite proteins inhibit IFNγ-induced expression of major histocompatibility complex class II on the surface of the infected cell in a dose-dependent response that was abolished by protease treatment.

TL;DR: The co-existence of these programs in Toxoplasma gondii-elicited inflammatory macrophages is reported, independent of parasite expression of the virulence factor ROP16 and host cell expression of signal transducer and activator of transcription 6 (STAT6).