David H. Lee
New York Medical College
5 Papers
10 Citations
David H. Lee is an academic researcher from New York Medical College. The author has contributed to research in topics: Lyme disease & Antibiotic prophylaxis. The author has an hindex of 5, co-authored 5 publications.
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Papers
Efficacy of antibiotic prophylaxis for the prevention of Lyme disease: an updated systematic review and meta-analysis
Stephen Warshafsky,David H. Lee,Louise K Francois,John Nowakowski,Robert B. Nadelman,Gary P. Wormser +5 more
TL;DR: The available evidence to date supports the use of antibiotic prophylaxis for the prevention of Lyme disease in endemic areas following an Ixodes tick bite, and pooled data from four placebo-controlled trials suggests that one case of Lyme Disease is prevented for about every 50 patients who are treated with antibiotics.
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INK4a knockout mice exhibit increased fibrosis under normal conditions and in response to unilateral ureteral obstruction.
TL;DR: Results confirm that p16(INK4a) controls cell proliferation and matrix production and mitigates fibrosis following injury and suggest that the mechanism involves a role in limiting inflammation and cell proliferation.
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INK4a deletion results in improved kidney regeneration and decreased capillary rarefaction after ischemia-reperfusion injury.
TL;DR: Results suggest that the absence of p16(INK4a) and p19(ARF) following IRI has a protective effect on the kidney through improved epithelial and microvascular repair, in part by enhancing the mobilization of myeloid cells into the kidney.
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Id Proteins Regulate Capillary Repair and Perivascular Cell Proliferation following Ischemia-Reperfusion Injury
TL;DR: Examination of gene expression in microvascular cells isolated from WT, Id1/Id3 KO and TRE Id1 mice showed increased Ang1 and αSMA in Id1 overexpressing cells and decreased pericyte markers in cells from KO mice, suggesting that increased Id levels following AKI result inmicrovascular remodeling associated with increased fibrosis.