David Gilad
Ben-Gurion University of the Negev
6 Papers
David Gilad is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Neurotransmission & Metabotropic receptor. The author has an hindex of 5, co-authored 6 publications.
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Papers
Upregulation of KCC2 Activity by Zinc-Mediated Neurotransmission via the mZnR/GPR39 Receptor
Ehud Chorin,Ofir Vinograd,Ilya A. Fleidervish,David Gilad,Sharon Herrmann,Israel Sekler,Elias Aizenman,Michal Hershfinkel +7 more
TL;DR: It is shown that physiological activation of mZnR signaling induces enhanced K+/Cl− cotransporter 2 (KCC2) activity and surface expression, elucidates a fundamentally important role for synaptically released Zn2+ acting as a neurotransmitter signal via activation of a mZNR to increase Cl− transport, thereby enhancing inhibitory tone in postsynaptic cells.
152
Synaptic Zn2+ Inhibits Neurotransmitter Release by Promoting Endocannabinoid Synthesis
Tamara Perez-Rosello,Charles T. Anderson,Francisco J. Schopfer,Yanjun Zhao,David Gilad,Sonia R. Salvatore,Bruce A. Freeman,Michal Hershfinkel,Elias Aizenman,Elias Aizenman,Thanos Tzounopoulos +10 more
TL;DR: It is discovered that synaptic Zn2+ and GPR39, a putative metabotropic Zn 2+-sensing receptor (mZnR), are necessary for triggering the synthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG).
83
Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures
David Gilad,Sharon Shorer,Maya Ketzef,Alon Friedman,Israel Sekler,Elias Aizenman,Michal Hershfinkel +6 more
TL;DR: It is suggested that mZnR/GPR39-dependent upregulation of KCC2 activity provides homeostatic adaptation to an excitotoxic stimulus by increasing inhibition, and may provide a novel pharmacological target for dampening epileptic seizure activity.
81
The zinc sensing receptor, ZnR/GPR39, in health and disease.
TL;DR: ZnR/GPR39 provides a unique target for therapeutically modifying the actions of zinc in a specific and selective manner, and plays a key role in mediating effects of Zn2+ in health and disease.
69
Anatomical Aspects in Recurrent Pregnancy Loss
Asher Bashiri,David Gilad,David Yohai,Tullio Ghi +3 more
- 01 Jan 2016
TL;DR: This chapter will review the role of the uterus in the pathophysiology of RPL and recommend strategies to improve the chance of good pregnancy outcome.