David Gerhold
National Institutes of Health
13 Papers
99 Citations
David Gerhold is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Adverse Outcome Pathway & Cancer. The author has an hindex of 8, co-authored 13 publications.
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Papers
Pathways of Toxicity.
Andre Kleensang,Alexandra Maertens,Michael Rosenberg,Suzanne Fitzpatrick,Justin Lamb,Scott S. Auerbach,Richard J. Brennan,Kevin M. Crofton,Ben Gordon,Albert J. Fornace,Kevin W. Gaido,David Gerhold,Robin Haw,Adriano Henney,Avi Ma'ayan,Mary McBride,Stefano Monti,Michael F. Ochs,Akhilesh Pandey,Roded Sharan,Rob H. Stierum,Stuart Tugendreich,Catherine Willett,Clemens Wittwehr,Jianguo Xia,Geoffrey W. Patton,Kirk Arvidson,Mounir Bouhifd,Helena T. Hogberg,Thomas Luechtefeld,Lena Smirnova,Liang Zhao,Yeyejide Adeleye,Minoru Kanehisa,Paul L. Carmichael,Melvin E. Andersen,Thomas Hartung +36 more
TL;DR: The Pathways of Toxicity (PoT) as discussed by the authors is a molecular definition of cellular processes shown to mediate adverse outcomes of toxicants, and it is further recognized that normal physiological pathways exist that maintain homeostasis and these can become PoTs.
A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives
Fabian A. Grimm,Yasuhiro Iwata,Oksana Sirenko,Grace A. Chappell,Fred A. Wright,David M. Reif,John C. Braisted,David Gerhold,Joanne M. Yeakley,Peter J. Shepard,Bruce Seligmann,Tim Roy,Peter J. Boogaard,Hans B. Ketelslegers,Arlean Rohde,Ivan Rusyn +15 more
TL;DR: An experimental and computational approach to categorizing UVCBs according to chemical and biological similarities is presented.
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Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening
Zhi Bin Tong,Helena T. Hogberg,David Kuo,Srilatha Sakamuru,Menghang Xia,Lena Smirnova,Thomas Hartung,Thomas Hartung,David Gerhold +8 more
TL;DR: Gene expression results suggest that differentiating LUHMES cells may be susceptible to apoptosis because they express low levels of anti‐apoptotic genes BCL2 and BIRC5/survivin, whereas SH‐SY5Y cells mayBe resistant to apoptotic genes, whereas NSCs may be resistant to oxidative stress.
Detection of Phospholipidosis Induction A Cell-Based Assay in High-Throughput and High-Content Format
TL;DR: A cell-based phospholipidosis assay has been developed using the LipidTOX Red reagent in HepG2 cells and miniaturized into a 1536-well plate format and confirmed using the EM method, demonstrating that this assay can be used to evaluate and profile large numbers of chemicals for drug-induced phospholIPidosis.
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Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies.
Menghang Xia,Ruili Huang,Qiang Shi,Windy A. Boyd,Jinghua Zhao,Nuo Sun,Julie R. Rice,Paul E Dunlap,Amber J. Hackstadt,Matthew F. Bridge,Marjolein V. Smith,Sheng Dai,Wei Zheng,Pei-Hsuan Chu,David Gerhold,Kristine L. Witt,Michael J. DeVito,Jonathan H. Freedman,Christopher P. Austin,Keith A. Houck,Russell S. Thomas,Richard S. Paules,Raymond R. Tice,Anton Simeonov +23 more
TL;DR: The tier-based approach for identifying and mechanistically characterizing mitochondrial toxicants can potentially reduce animal use in toxicological testing.