David G. Sciberras
Merck & Co.
16 Papers
228 Citations
David G. Sciberras is an academic researcher from Merck & Co.. The author has contributed to research in topics: Hemodynamics & Medicine. The author has an hindex of 13, co-authored 16 publications. Previous affiliations of David G. Sciberras include Hammersmith Hospital.
Chat about Author
Papers
Elimination and Biochemical Responses to Intravenous Alendronate in Postmenopausal Osteoporosis
S. Khan,John A. Kanis,Samuel D Vasikaran,W. F. Kline,Bogdan K. Matuszewski,Eugene V. McCloskey,Monique N.C. Beneton,Barry J. Gertz,David G. Sciberras,Sherry D. Holland,J. Orgee,G. Coombes,S. Rogers,Arturo G. Porras +13 more
TL;DR: It is concluded that a short course of high doses of intravenous alendronate is associated with a prolonged skeletal retention of the agent, and suggests that this regimen has a sustained effect on bone turnover persisting for at least 1 year.
302
Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant.
Mats Bergström,Richard Hargreaves,H. Donald Burns,Michael R. Goldberg,David G. Sciberras,Scott A. Reines,Kevin J. Petty,Mattias Ögren,Gunnar Antoni,Bengt Långström,Olli Eskola,Mika Scheinin,Olof Solin,Anup K. Majumdar,M.L Constanzer,Wendy P Battisti,Thomas E. Bradstreet,Cynthia Gargano,Jarmo Hietala +18 more
TL;DR: Positron emission tomography imaging with [(18)F]SPA-RQ allows brain NK( 1) receptor occupancy by aprepitant to be predicted from plasma drug concentrations and can be used to guide dose selection for clinical trials of NK(1) receptor antagonists in central therapeutic indications.
208
Comparison of angiotensin-converting enzyme inhibition with angiotensin II receptor antagonism in the human forearm.
TL;DR: Analysis of variance for repeated measures indicated that losartan inhibited constriction to ANG I and ANG II in a dose-dependent manner without significantly influencing vasodilator responses to bradykinin.
94
Intra-arterial substance P mediated vasodilatation in the human forearm: pharmacology, reproducibility and tolerability
David E. Newby,David G. Sciberras,Carl M. Mendel,Barry J. Gertz,Nicholas A. Boon,David J. Webb +5 more
TL;DR: Forearm vasodilatation to substance P represents a reproducible and useful model in the assessment of peripheral endothelial cell NK1 receptor function.
46
Substance P-induced vasodilatation is mediated by the neurokinin type 1 receptor but does not contribute to basal vascular tone in man.
David E. Newby,David G. Sciberras,Charles J. Ferro,Barry J. Gertz,David Sommerville,Anup Majumdar,Richard C. Lowry,David J. Webb +7 more
TL;DR: Substantial substance P induced forearm vasodilatation is mediated by the endothelial cell NK1 receptor in man but endogenous substance P does not appear to contribute to the maintenance of peripheral vascular tone or systemic blood pressure.
44