David G. Hendrickson
Harvard University
32 Papers
267 Citations
David G. Hendrickson is an academic researcher from Harvard University. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 15, co-authored 28 publications. Previous affiliations of David G. Hendrickson include Broad Institute & Stanford University.
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Papers
Differential analysis of gene regulation at transcript resolution with RNA-seq
Cole Trapnell,David G. Hendrickson,David G. Hendrickson,Martin Sauvageau,Martin Sauvageau,Loyal A. Goff,Loyal A. Goff,John L. Rinn,John L. Rinn,Lior Pachter +9 more
TL;DR: Cuffdiff 2, an algorithm that estimates expression at transcript-level resolution and controls for variability evident across replicate libraries, robustly identifies differentially expressed transcripts and genes and reveals differential splicing and promoter-preference changes.
Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre
Ezgi Hacisuleyman,Loyal A. Goff,Cole Trapnell,Adam Williams,Jorge Henao-Mejia,Lei Sun,Patrick D. McClanahan,David G. Hendrickson,Martin Sauvageau,David R. Kelley,Michael A. Morse,Jesse M. Engreitz,Eric S. Lander,Mitch Guttman,Harvey F. Lodish,Richard A. Flavell,Arjun Raj,John L. Rinn +17 more
TL;DR: One lncRNA, Firre, is described that interacts with the nuclear-matrix factor hnRNPU through a 156-bp repeating sequence and localizes across an ~5-Mb domain on the X chromosome, suggesting a model in which lncRNAs such as Firre can interface with and modulate nuclear architecture across chromosomes.
Long noncoding RNAs regulate adipogenesis
Lei Sun,Loyal A. Goff,Cole Trapnell,Ryan Alexander,Kinyui Alice Lo,Ezgi Hacisuleyman,Martin Sauvageau,Martin Sauvageau,Barbara Tazon-Vega,David R. Kelley,David G. Hendrickson,Bingbing Yuan,Manolis Kellis,Harvey F. Lodish,John L. Rinn +14 more
TL;DR: The transcriptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes is profiled and 175 lncRNAs that are specifically regulated during adipogenesis are identified that are functionally required for proper adipogenesis.
Programming human pluripotent stem cells into white and brown adipocytes
Tim Ahfeldt,Robert T. Schinzel,Youn-Kyoung Lee,David G. Hendrickson,David G. Hendrickson,Adam Kaplan,David H. Lum,David H. Lum,Raymond Camahort,Fang Xia,Jennifer Shay,Eugene P. Rhee,Eugene P. Rhee,Clary B. Clish,Rahul C. Deo,Tony Shen,Frank H. Lau,Alicia Cowley,Greg Mowrer,Heba Al-Siddiqi,Matthias Nahrendorf,Kiran Musunuru,Kiran Musunuru,Kiran Musunuru,Robert E. Gerszten,Robert E. Gerszten,John L. Rinn,John L. Rinn,Chad A. Cowan +28 more
TL;DR: The robust and efficient differentiation of human pluripotent stem cells into white or brown adipocytes is reported, indicating that the cells could be used to faithfully model human disease.
Systematic Identification of mRNAs Recruited to Argonaute 2 by Specific microRNAs and Corresponding Changes in Transcript Abundance
TL;DR: A comprehensively assessing the miRNAs and mRNAs that are physically associated with Argonaute 2 (Ago2), which is a core RISC component, found that Ago2 immunopurified samples contained a representative repertoire of the cell's mi RNAs and a select subset of thecell's total m RNAs.